An 82-year-old man, who 7 years previously had been treated for adenocarcinoma of the prostate, was found to have developed a small cell (oat cell) carcinoma of prostate, which presented with liver metastases. The expression of different neuroendo crine markers in these carcinomas is presented, the histogenesis of small cell carcinoma is discussed, and the relevant literature is reviewed. The importance of the recognition of small cell carcinoma of the prostate is emphasized because of the influence of small cell carcinoma on the prognosis. Int J Surg Pathol 2(3):237-244, 1995
Di-Sant'Agnese PA. Neuroendocrine differentation in human prostatic carcinoma. Hum Pathol23: 287-296, 1992
2.
Ro JY, Tetu B., Ayala AG, Ordonez NGSmall cell carcinoma of the prostate. II Immunohistochemical and electron microscopic studies of 18 cases. Cancer59:977-982, 1987
3.
Di-Sant'Agnese PANeuroendocrine differentiation and prostatic carcinoma. The concept "comes of age". Arch Pathol Lab Med112:1097-1099, 1988
4.
Tetu B., Ro JY, Ayala AG, Johnson DE, Logothetis CJ, Ordonez NGSmall cell carcinoma of the prostate. I. A clinicopathologic study of 20 cases . Cancer59: 1803-1809, 1987
5.
Adshead F., De Graeff A., Mansi JL, Thomas DMSmall cell carcinoma of the prostate: Implications for management . Br J Urol67:217-219, 1991
6.
Amato RJ, Lagothetis CJ, Hallinan R., Ro JY, Sella A., Dexeus FHChemotherapy for small cell carcinoma of prostatic origin. J Urol147:935-937, 1992
7.
Hagood PG, Johnson FE, Bedrossian Cwm, Silverbeg ABSmall cell carcinoma of the prostate. Cancer67:1046-1050, 1991
8.
Oesterling JE , Hauzeur CG, Farrow GMSmall cell anaplastic carcinoma of the prostate: A clinical, pathological and immunohistological study of 27 patients. J Urol147:804-807, 1992
9.
Freedy RM, Miller KD Jr. Small cell carcinoma of the prostate: Metastases to the brain as shown by CT and MR with pathologic correlation. Am J Neuroradiol11:947-948, 1990
10.
Manson AL, Terhune D., MacDonald G.Small cell carcinoma of prostate. Urology33:78-79, 1989
11.
Sarma DP, Weilbaecher TGSmall cell carcinoma of prostate. Urology33:332-335, 1989
12.
Ghali VS, Garcia RLProstatic adenocarcinoma with carcinoidal features producing adrenocorticotrophic syndrome: Immunohistochemical study and review of the literature. Cancer54:1043-1048, 1984
13.
Vuitch MF, Mendelsohn G.Relationship of ectopic ACTH production to tumour differentiation: A morphologic and immunohistochemical study of prostatic carcinoma with Cushing's syndrome . Cancer47:296-299, 1981
14.
Wenk RE, Bhagavan BS, Levy R., Miller D., Weisburger W.Ectopic ACTH, prostate oat cell carcinoma and marked hypernatremia . Cancer40:773-778, 1977
15.
Ghandur-Mnaymneh L., Satterfield S., Block NLSmall cell carcinoma of the prostate gland with inappropriate antidiuretic hormone secretion: Morphological, immunohistochemical and clinical expressions. J Urol135:1263-1266, 1986
16.
Smith DC, Tucker A., Trump DLHypercalcaemia and neuroendocrine carcinoma of the prostate: A report of three cases and a review of the literature. J Clin Oncol10:499-505, 1992
17.
Turbat-Herrera EA, Herrera GA, Gore I., Loth RL, Grizzle WE, Bonnin JMNeuroendocrine differentiation in prostatic carcinomas. A retrospective autopsy study. Arch Pathol Lab Med112:1100-1105, 1988
18.
Tetu B., Roy JY, Ayala AG, Ordonez NG, Logothetis CJ, von Eschenbach ACSmall cell carcinoma of prostate associated with myasthenic (Eaton-Lambert) syndrome. Urology33:148-152, 1989
19.
Schron DS, Gipson T., Mendelsohn G.The histogenesis of small cell carcinoma of the prostate. An immunohistochemical study. Cancer53:2478-2480, 1984
20.
Yu DS, Chang SY, Wang J., Yang TH, Cheng CL, Lee SS, Ma CMSmall cell carcinoma of the urinary tract. Brit J Urol66:590-595, 1990
21.
Azzopardi JG , Evans DJArgentaffin cells in prostatic carcinoma: Differentiation from lipofuscin and melanin in prostatic epithelium . J Pathol104:247-251, 1971
22.
Fetissof F. , Dubois MP, Arbeille-Brassart B., Lanson Y., Boivin F., Jobard P.Endocrine cells in the prostate gland, urothelium and Brenner tumours. Immunohistological and ultrastructural studies. Virchows Arch Cell Pathol42:53-64, 1983
23.
Kazzaz BAArgentaffin and argyrophil cells in the prostate. J Pathol112:189-193, 1974
24.
Di-Sant'Agnese PA, Davis NS, Chen M., De Mesy Jensen KLAge-related changes in the neuroendocrine (endocrine-paracrine) cell population and the serotonin content of the guinea pig prostate. Lab Invest57:729-736, 1987
25.
Di-Sant'Agnese PA, De Mesy Jensen KLNeuroendocrine differentiation in prostatic carcinoma. Hum Pathol18:849-856, 1987
26.
Abrahamsson PA, Wadstrom LB, Alumets J., Falker S., Grimelius L.Peptide-hormone and serotonin—immunoreactive tumour cells in carcinoma of the prostate . Pathol Res Pract182:298-307, 1987
27.
Stevens RE, Moore GEInadequacy of APUD concept in explaining production of peptide hormones by tumours. Lancet1:118-119, 1983
28.
De Lellis RA , Tischler AS, Wolfe HJMultidirectional differentiation in neuroendocrine neoplasms. J Histochem Cytochem32:899-904, 1984
29.
Gould VE, Lee I., Warren WHImmunohistochemical evaluation of neuroendocrine cells and neoplasms of the lung. Pathol Res Pract183:200-213, 1988
30.
Kirkland SCEndocrine differentiation by a human rectal adenocarcinoma cell line (HRA-19) . Differentiation33:148-155, 1986
31.
Del Buono R. , Pignatelli M., Hall PAControl of differentiation in a rectal adenocarcinoma cell line: The role of diffusable and cell-associated factors. J Pathol164:59-66, 1991
32.
Van Haaften-Day C, Raghavan D., Russell P., Willis EJ, Gregory P., Tilley W., Horsfall DJXenografted small cell undifferentiated cancer of prostate: Possible common origin with prostatic adenocarcinoma. Prostate11:271-279, 1987
33.
Jelbart ME, Russell PJ, Fullerton M., Russell P., Funder J., Raghavan D.Ectopic hormone production by a prostatic small cell carcinoma xenograft line . Mol Cell Endocrinol55:167-172, 1988
