Abstract
Renal cell carcinoma (RCC) with hemangioblastoma-like features, which was not included in the 2022 edition of the World Health Organization Classification of Tumors of the Urinary System and Male Genital Organs, is an extremely rare RCC reported in recent years. Due to the morphological and immunophenotypic overlap of RCC with hemangioblastoma-like features and renal hemangioblastoma, this might be a potential pitfall or conundrum in histopathological diagnosis. To reinforce the knowledge of this rare tumor, we present an example of RCC with hemangioblastoma-like features with leiomyomatous stroma and renal vein invasion in a 59-year-old man and confirm the diagnosis by histopathological examination and immunohistochemistry. In addition, we discuss its clinicopathological features and molecular characteristics by reviewing the relevant literature.
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