Plexiform fibromyxoma (PF) is an exceptionally rare benign mesenchymal tumor of the gastrointestinal tract, primarily affecting the gastric antrum. We present a detailed case report of a 67-year-old female patient who underwent diagnostic and therapeutic endoscopic procedures for a suspected gastrointestinal stromal tumor (GIST) initially identified during an upper endoscopy. Subsequent examination and pathology confirmed a diagnosis of PF in the gastric body following endoscopic mucosal resection. This report discusses the clinical presentation, diagnostic approach, histological findings, management strategies, and review of current literature on PF.
TakahashiYShimizuSIshidaT, et al.Plexiform angiomyxoid myofibroblastic tumor of the stomach. Am J Surg Pathol.2007;31(5):724-728. doi:10.1097/01.PAS.0000213448.54643.2F
2.
SuHYenHChenC. An update on clinicopathological and molecular features of plexiform fibromyxoma. Can J Gastroenterol Hepatol. 2019;2019:1-26. doi:10.1155/2019/3960920
3.
World Health Organization. Digestive system tumours. 5th ed.International Agency for Research on Cancer; 2019(WHO Classification of Tumours Series, Vol. 1).
4.
TakahashiYShimizuSIshidaT, et al.Plexiform angiomyxoid myofibroblastic tumor of the stomach. Am J Surg Pathol. 2007;31(5):724-728. doi:10.1097/01.pas.0000213448.54643.2f
5.
ArslanMELiHFuZJenningsTALeeH. Plexiform fibromyxoma: Review of rare mesenchymal gastric neoplasm and its differential diagnosis. World J Gastrointest Oncol.2021;13(5):409-423. doi:10.4251/wjgo.v13.i5.409
6.
HirotaS. Differential diagnosis of gastrointestinal stromal tumor by histopathology and immunohistochemistry. Transl Gastroenterol Hepatol. 2018;3:27. doi:10.21037/tgh.2018.04.01
7.
ChenHZhaoHXieYJinM. Clinicopathological features and differential diagnosis of aggressive angiomyxoma of the female pelvis. Medicine (Baltimore).2017;96(20):e6820. doi:10.1097/md.0000000000006820
8.
MaccagnoASanderBDintnerSHarloffMFüzesiLMärklB. Inflammatory fibroid polyp: A series of 29 cases and a systematic review of the literature. Hum Pathol Rep. 2023;32:300703. doi:10.1016/j.hpr.2023.300703
9.
McCarthyAJChettyR. Benign smooth muscle tumors (leiomyomas) of deep somatic soft tissue. Sarcoma. 2018;2018:1-6. doi:10.1155/2018/2071394
10.
VoltaggioLMurrayRLasotaJMiettinenM. Gastric schwannoma: A clinicopathologic study of 51 cases and critical review of the literature. Hum Pathol.2012;43(5):650-659. doi:10.1016/j.humpath.2011.07.006
11.
GarroucheNAbdallahABArifaN, et al.Spectrum of gastrointestinal lesions of neurofibromatosis type 1: A pictorial review. Insights Imaging.2018;9(5):661-671. doi:10.1007/s13244-018-0648-8
12.
GuoALiuAWeiLSongX. Malignant peripheral nerve sheath tumors: Differentiation patterns and immunohistochemical features—A mini-review and our new findings. J Cancer.2012;3:303-309. doi:10.7150/jca.4179
13.
ParkJYParkNJKimSPKwonKYLeeSS. A soft tissue perineurioma and a hybrid tumor of perineurioma and schwannoma. Korean J Pathol. 2012;46(1):75. doi:10.4132/koreanjpathol.2012.46.1.75
14.
SpansLFletcherCDMAntonescuCR, et al.Recurrent MALAT1–GLI1 oncogenic fusion and GLI1 up-regulation define a subset of plexiform fibromyxoma. J Pathol.2016;239(3):335-343. doi:10.1002/path.4730
15.
RawlinsonNJWestWWNelsonM, et al.Aggressive angiomyxoma with t(12;21) and HMGA2 rearrangement: Report of a case and review of the literature. Cancer Genet Cytogenet.2008;181(2):119-124. doi:10.1016/j.cancergencyto.2007.11.008
16.
SchildhausH-UBüttnerRBinotEMerkelbach-BruseSWardelmannE. Inflammatory fibroid polyps are true neoplasms with PDGFRA mutations. Pathologe. 2009;30(Suppl. 2):117-120. doi:10.1007/s00292-009-1196-2
17.
SøreideKSandvikOMSøreideJAGiljacaVJureckovaABulusuVR. Global epidemiology of gastrointestinal stromal tumours (GIST): A systematic review of population-based cohort studies. Cancer Epidemiol.2016;40:39-46. doi:10.1016/j.canep.2015.10.031
RossiPMontuoriMBalassoneV, et al.Inflammatory fibroid polyp: A case report and review of the literature. Ann Ital Chir.2012;83(4):347-351. https://pubmed.ncbi.nlm.nih.gov/22759473/
20.
AlpertLAl-SabtiRGrahamRP, et al.Smooth muscle tumors of the gastrointestinal tract: An analysis of prognostic features in 407 cases. Mod Pathol.2020;33(7):1410-1419. doi:10.1038/s41379-020-0492-5
21.
PengHHanLTanY, et al.Clinicopathological characteristics of gastrointestinal schwannomas: A retrospective analysis of 78 cases. Front Oncol.2022;12:1003895. doi:10.3389/fonc.2022.1003895
22.
HondaMIwamuroMTanakaT, et al.Frequency and characteristics of gastrointestinal diseases in patients with neurofibromatosis. JGH Open. 2025;9(4):e70151. doi:10.1002/jgh3.70151
23.
MoweryAClayburghD. Malignant peripheral nerve sheath tumors: Analysis of the national cancer database. Oral Oncol.2019;98:13-19. doi:10.1016/j.oraloncology.2019.09.010
24.
AleneziAFJahramiHKanberYBessissowT. Gastrointestinal tract perineuriomas and benign fibroblastic polyps: Case report and comprehensive systematic review. Case Rep Gastrointest Med.2025;2025:1636142. doi:10.1155/crgm/1636142
25.
MiettinenMMakhloufHRSobinLHLasotaJ. Plexiform fibromyxoma: A distinctive benign gastric antral neoplasm not to be confused with a myxoid GIST. Am J Surg Pathol.2009;33(11):1624-1632. doi:10.1097/PAS.0b013e3181ae666a
26.
XiaZZhouZGuoW, et al.Endoscopic submucosal excavation for gastric plexiform fibromyxoma: A case report and systematic review of literature. Front Oncol.2023;13. doi:10.3389/fonc.2023.1090259
27.
KrishnanSKChirukandathRZachariahTThomasRS. An unusual stomach tumour: Plexiform angiomyxoid fibroma stomach—A case report. Indian J Surg Oncol.2022;13(4):691-695. doi:10.1007/s13193-022-01625-4
28.
AyyanarPNayakHKSamalSCKarMMishraPPatraS. Recurrent plexiform angiomyxoid myofibroblastic tumour (PAMT) of the stomach with aggressive behaviour. Pathology. 2022;54(5):650-654. doi:10.1016/j.pathol.2021.09.010
