Neuroblastomas in adults are extremely rare and are generally regarded to have poorer outcomes compared to infants and children. Due to the scarcity of data among adult patients with neuroblastoma, treatment guidelines are also not well established. These tumors are derived from primitive neural crest cells and fall under a broader category of small round blue cell tumors which can pose diagnostic challenges in atypical scenarios like adult patients or atypical primary sites. Accurate diagnosis is vital to appropriate patient management. We present one such rare occurrence of a mediastinal neuroblastoma in a 31-year-old adult woman presenting with neurological symptoms after a prolonged indolent course.
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