Combined ganglioneuroma-schwannoma is an exceedingly rare tumor that has only been described in isolated case reports. We document a 64-year-old man with an incidentally discovered combined ganglioneuroma-schwannoma of the retroperitoneum that was intimately associated with sympathetic ganglia. We highlight the morphological and immunohistochemical findings of this rare tumor, and show evidence of its origin from sympathetic ganglia.
LebbyEKwanDBuiTLO’ConnellRSeetharamanMHoushyarR. Retroperitoneal ganglioneuroma with nodal involvement in an adult patient with human immunodeficiency virus: a case report and review of the literature. J Med Case Rep. 2021;15(1):634. doi:https://doi.org/10.1186/s13256-021-03134-4
EdoHHyoueEHamamotoK, et al.Composite pheochromocytoma-ganglioneuroma: a case with two distinct components radiographically. BJR Case Rep. 2022;8(5):20220079. doi:https://doi.org/10.1259/bjrcr.20220079
4.
IacoboneMTorresanFCittonMSchiavoneDVielGFaviaG. Adrenal ganglioneuroma: the Padua endocrine surgery unit experience. Int J Surg. 2017;41(Suppl 1):S103-S108. doi:https://doi.org/10.1016/j.ijsu.2017.03.086
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ShanoudaSKayaG. Benign cutaneous peripheral nerve sheath tumor with hybrid features: report of two cases with schwannoma/perineurioma and schwannoma/neurofibroma components. Dermatopathology (Basel). 2017;4(1-4):1-6. doi:https://doi.org/10.1159/000478854
ParaskevopoulosKChevaAPapaemmanuilSVahtsevanosKAntoniadesK. Synchronous ganglioneuroma and schwannoma mistaken for carotid body tumor. Case Rep Otolaryngol. 2017;2017(1):7973034. doi:https://doi.org/10.1155/2017/7973034
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MylonasKSSchizasDEconomopoulosKP. Adrenal ganglioneuroma: what you need to know. World J Clin Cases. 2017;5(10):373-377. doi:https://doi.org/10.12998/wjcc.v5.i10.373
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LiuSTianYChlenskiA, et al.Cross-Talk between Schwann cells and neuroblasts influences the biology of neuroblastoma Xenografts. Am J Pathol. 2005;166(3):891-900. doi:https://doi.org/10.1016/S0002-9440(10)62309-7
DamianiSManettoVCarrilloGDi BlasiANappiOEusebiV.Malignant peripheral nerve sheath tumor arising in a « De Novo » ganglioneuroma. a case report. Tumori J. 1991;77(1):90-93. doi:https://doi.org/10.1177/030089169107700121
