Sage Journals: Discover world-class research

Abstract

Atrophic kidney-like lesion (AKLL) is a rare kidney lesion, which was recently suggested by the Genitourinary Pathology Society as a provisional entity. As of now, 16 examples of AKLL have been described in the literature. Here we report a new tumor which shows similar clinicopathologic characteristics with those previously reported in AKLL. Immunohistochemical (IHC) studies in the current lesion identified a biphasic staining pattern consisting of a mixture of WT1+/KRT7-/PAX8- large dilated cysts and WT-/KRT7+/PAX8+ small atrophic cysts. Histomorphologic features of AKLL overlap with several neoplastic and non-neoplastic entities which can lead to mischaracterization. Awareness of the differentiating features is likely important when evaluating these lesions.

Keywords

atrophic kidney-like lesion provisional entity tumor characterization kidney tumor

Get full access to this article

View all access options for this article.

References

Hes

de Souza

Pivovarcikova

, et al. Distinctive renal cell tumor simulating atrophic kidney with 2 types of microcalcifications. Report of 3 cases. Ann Diagn Pathol. 2014;18(2):82-88. doi: https://doi.org/10.1016/j.anndiagpath.2013.12.003

Trpkov

Williamson

Gill

, et al. Novel, emerging and provisional renal entities: the Genitourinary Pathology Society (GUPS) update on renal neoplasia. Mod Pathol. 2021;34(6):1167-1184. doi: https://doi.org/10.1038/s41379-021-00737-6

Herlitz

Hes

Michal

, et al. “Atrophic kidney”-like lesion: clinicopathologic series of 8 cases supporting a benign entity distinct from thyroid-like follicular carcinoma. Am J Surg Pathol. 2018;42(12):1585-1595. doi: https://doi.org/10.1097/PAS.0000000000001157

Muscara

Simper

Gandia

. Thyroid-like follicular carcinoma of the kidney. Int J Surg Pathol. 2016;25(1):73-77. doi: https://doi.org/10.1177/1066896916662153

Berens

Vogt

Alkadhi

Berger

Moch

. Das schilddrüsenähnliche follikuläre Nierenzellkarzinom: eine eigene Tumorentität? [Thyroid-like follicular carcinoma of the kidney: a separate tumor entity?]. Pathologe. 2014;35(1):83-87. German. doi: https://doi.org/10.1007/s00292-013-1772-3.

Dong

Huang

, et al. Thyroid-like follicular carcinoma of the kidney in a patient with skull and meningeal metastasis: a unique case report and review of the literature. Medicine (Baltimore). 2016;95(15):e3314. doi: https://doi.org/10.1097/MD.0000000000003314

Akgul

Williamson

. Immunohistochemistry for the diagnosis of renal epithelial neoplasms. Semin Diagn Pathol. 2022;39(1):1-16. doi: https://doi.org/10.1053/j.semdp.2021.11.001

Oshiro

Hida

Tamiya

, et al. Bilateral atrophic kidney-like tumors. Pathol Int. 2014;64(9):478-480. doi: https://doi.org/10.1111/pin.12193

Amin

Gupta

Ondrej

, et al. Primary thyroid-like follicular carcinoma of the kidney: report of 6 cases of a histologically distinctive adult renal epithelial neoplasm. Am J Surg Pathol. 2009;33(3):393-400. doi: https://doi.org/10.1097/PAS.0b013e31818cb8f5

10.

Thirunavukkarasu

Singh

Sharma

Bal

. Atrophic kidney-like lesion - case report of a provisional entity with brief review of literature. Turk Patoloji Derg. 2022;38(2):148-152. doi: https://doi.org/10.5146/tjpath.2021.01541

11.

Goel

Modi

. Atrophic kidney-like lesion: a rare benign entity and mimicker of thyroid follicular-like carcinoma of kidney. Indian J Pathol Microbiol. 2023;66(1):180-183. doi: https://doi.org/10.4103/IJPM.IJPM_1107_21

12.

Gurel

Narra

Elsayes

Siegel

Chen

Brown

. Subtypes of renal cell carcinoma: MRI and pathological features. Diagn Interv Radiol. 2013;19(4):304-311. doi: https://doi.org/10.5152/dir.2013.147

13.

Bissler

Siroky

Yin

. Glomerulocystic kidney disease. Pediatr Nephrol. 2010;25(10):2049-2056; quiz 2056-9. doi: https://doi.org/10.1007/s00467-009-1416-2.

Atrophic Kidney-Like Lesion—Case Report and Review of the Literature

Abstract

Keywords

Get full access to this article

References