We report a patient with isolated stromal lipofuscinosis of the seminal vesicle, a rare entity characterized by intracytoplasmic pigmented granules within stromal cells intimately surrounding seminal vesicle epithelium. Only 4 patients with this unusual phenomenon have been previously reported in the literature. Recognizing this incidental and presumably non-pathologic finding is important to prevent misclassification as a more concerning lesion.
BrennickJBO'ConnellJXDickersinGRPilchBZYoungRH. Lipofuscin pigmentation (so-called “melanosis”) of the prostate. Am J Surg Pathol. 1994;18(5):446-454.
2.
TermanABrunkUT. Lipofuscin. Int J Biochem Cell Biol. 2004;36(8):1400-1404.
3.
AlbrechtHHagelAde RossiT, et al.Brown bowel syndrome: a rare complication in diseases associated with long-standing malabsorption. Digestion. 2014;89(2):105-109.
4.
SchnedARBrennickJBGonzalezJL. Stromal lipofuscinosis of the seminal vesicle. Pathology. . 2010;42(2):177-179.
5.
SangkhamanonSMedlicottSACTrpkovK. Stromal lipofuscinosis of the seminal vesicle: incidental finding in two patients treated for prostatic adenocarcinoma by prostatectomy and cryotherapy. Human Pathology: Case Reports. 2018;11(2214-3300):21-24.
6.
GucerHBagciP. Prostatic melanosis. Urol Ann. 2014;6(4):384-386.
7.
KlockCGomesRJoãoMNettoG. Prostate melanosis associated with acinar adenocarcinoma. Int J Surg Pathol. 2010;18(5):379-380.
8.
DaileyVLHameedO. Blue nevus of the prostate. Arch Pathol Lab Med. 2011;135(6):799-802.
9.
SadiminETEpsteinJI. Round cell pattern of prostatic stromal tumor of uncertain malignant potential: a subtle newly recognized variant. Hum Pathol. 2016;52(0046-8177):68-73.
10.
HanselDEHerawiMMontgomeryEEpsteinJI. Spindle cell lesions of the adult prostate. Mod Pathol. 2007;20(1):148-158.
11.
HerawiMEpsteinJI. Specialized stromal tumors of the prostate: a clinicopathologic study of 50 cases. Am J Surg Pathol. 2006;30(6):694-704.
12.
ReikieBAYilmazAMedlicottSTrpkovK. Mixed epithelial-stromal tumor (MEST) of seminal vesicle: a proposal for unified nomenclature. Adv Anat Pathol. 2015;22(2):113-120.
13.
DebnathACheriyanADanielSJohnNT. Laparoscopic resection of a large mixed epithelial-stromal tumour of the seminal vesicle: a rare entity and review of the current literature. BMJ Case Rep. 2021;14(2). Article ID: e238526.
