Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a relatively rare mature T-cell lymphoma that cannot be categorized under any of the well-defined category. This type of aggressive lymphoma mostly involves the lymph nodes, though any other organ can be affected. Leukemic presentation is extremely rare. No case report of isolated leukemic presentation was found after detail literature search. Herein we present a case of PTCL, NOS with leukemic presentation.
AgostinelliCPiccalugaPPWentP, et al.Peripheral T cell lymphoma, not otherwise specified: the stuff of genes, dreams and therapies. J Clin Pathol. 2008;61(11):1160‐1167 doi:10.1136/jcp.2008.055335
4.
WeisenburgerDDSavageKJHarrisNL, et al.Peripheral T-cell lymphoma, not otherwise specified: a report of 340 cases from the International Peripheral T-cell Lymphoma Project. Blood. 2011;117(12):3402‐3408.
5.
KanavarosPBoullandMLPetitBArnulfBGaulardP. Expression of cytotoxic proteins in peripheral T-cell and natural killer-cell (NK) lymphomas: association with extranodal site, NK or Tgammadelta phenotype, anaplastic morphology and CD30 expression. Leuk Lymphoma. 2000;38(3-4):317‐326 doi: 10.3109/10428190009087022. PMID: 10830738.
6.
WentPAgostinelliCGallaminiA, et al.Marker expression in peripheral T-cell lymphoma: a proposed clinical-pathologic prognostic score. J Clin Oncol. 2006;24(16):2472‐2479. doi: 10.1200/JCO.2005.03.6327. Epub 2006 Apr 24 PMID: 16636342.
7.
SwerdlowSHJaffeESBroussetP, et al.Cytotoxic T-cell and NK-cell lymphomas: current questions and controversies. Am J Surg Pathol. 2014;38(10):e60‐e71. doi:10.1097/PAS.0000000000000295
8.
SabattiniEPizziMTabanelliV, et al.CD30 Expression in peripheral T-cell lymphomas. Haematologica. 2013;98(8):e81‐e82. doi:10.3324/haematol.2013.084913
9.
KawamotoKMiyoshiHYanagidaE, et al.Comparison of clinicopathological characteristics between T-cell prolymphocytic leukemia and peripheral T-cell lymphoma, not otherwise specified. Eur J Haematol. 2017;98(5):459‐466. doi: 10.1111/ejh.12856. Epub 2017 Mar 3 PMID: 28129454.
10.
NelsonMHorsmanDEWeisenburgerDD, et al.Cytogenetic abnormalities and clinical correlations in peripheral T-cell lymphoma. Br J Haematol. 2008;141(4):461‐469.
