We present a rare case of a 42-year-old man diagnosed with a placental site trophoblastic tumor in combination with teratoma in a mediastinal recurrence of a testicular germ cell tumor post-orchiectomy and chemotherapy. To the best of our knowledge, this is the eighth case of placental site trophoblastic tumor in a male reported so far in the English literature. The purpose of this case report is to add data to the existing literature, review the literature, discuss the differential diagnoses with emphasis on morphologic and immunohistochemical differences between trophoblastic tumors, and highlight the management implications of a correct diagnosis.
KurmanRJScullyRENorrisHJ. Trophoblastic pseudotumor of the uterus: an exaggerated form of “syncytial endometritis” simulating a malignant tumor. Cancer. 1976;38(3):1214‐1226.
2.
UlbrightTMYoungRHScullyRE. Trophoblastic tumors of the testis other than classic choriocarcinoma: “monophasic” choriocarcinoma and placental site trophoblastic tumor: a report of two cases. Am J Surg Pathol. 1997;21(3):282‐288.
3.
SuurmeijerAJHGietemaJAHoekstraHJ. Placental site trophoblastic tumor in a late recurrence of a nonseminomatous germ cell tumor of the testis. Am J Surg Pathol. 2004;28(6):830‐833.
4.
LeowWQLohHLALeeLSGohCHR. A rare case of combined placental site trophoblastic tumour with mature cystic teratoma and mixed germ cell tumour in the testis. Malays J Pathol. 2015;37(2):145‐147.
5.
BillèAGirelliLColecchiaMPastorinoU. Single synchronous pulmonary metastasis from placental site trophoblastic tumor and teratoma. Tumori. 2015;101(3):e110‐e111.
6.
RazafimahefaJGossetCCulineSMongiat-ArtusPVerineJ. Placental site trophoblastic tumor in nonseminomatous mixed germ cell tumors of the testis: a case report and review of the literature. Clin Genitourin Cancer. 2018;16(2):e349‐e354.
7.
IdreesMTKaoCSEpsteinJIUlbrightTM. Nonchoriocarcinomatous trophoblastic tumors of the testis: the widening Spectrum of trophoblastic neoplasia. Am J Surg Pathol. 2015;39(11):1468‐1478.
8.
WilliamsonSRDelahuntBMagi-GalluzziC, et al.The world health organization 2016 classification of testicular germ cell tumours: a review and update from the international society of urological pathology testis consultation panel. Histopathology. 2017;70(3):335‐346.
9.
ShihIM. Trophogram, an immunohistochemistry-based algorithmic approach, in the differential diagnosis of trophoblastic tumors and tumorlike lesions. Ann Diagn Pathol. 2007;11(3):228‐234.
10.
StichelboutMDevismeLFranquet-AnsartH, et al.SALL4 Expression in gestational trophoblastic tumors: a useful tool to distinguish choriocarcinoma from placental site trophoblastic tumor and epithelioid trophoblastic tumor. Hum Pathol. 2016;54:121‐126.
11.
GadducciACarinelliSGuerrieriMEAlettiGD. Placental site trophoblastic tumor and epithelioid trophoblastic tumor: clinical and pathological features, prognostic variables and treatment strategy. Gynecol Oncol. 2019;153(3):684‐693.
