Collision tumors are rare and there have only been a few previously described cases between an intestinal adenoma and a lymphoma. We report the first case of a 74-year-old woman who on investigation for iron deficiency had a tubulovillous adenoma with underlying follicular lymphoma. The atypical lymphoid proliferation showed immunohistochemical positivity for cluster of differentiation 20 (CD20), B-cell lymphoma 2 (BCL2), and B-cell lymphoma 6 (BCL6). Subsequent right hemicolectomy showed a superficially invasive adenocarcinoma.
KimSJChoiCWMunYC, et al. Multicenter retrospective analysis of 581 patients with primary intestinal non-Hodgkin lymphoma from the consortium for improving survival of lymphoma (CISL). BMC Cancer. 2011;11:321.
3.
YoshinoTMiyakeKIchimuraK, et al. Increased incidence of follicular lymphoma in the duodenum. Am J Surg Pathol. 2000;24:688-693.
4.
HimchakEMarksEShiYWangY. Did I miss it? Discovering hidden coexisting hematological neoplasms: a single institutional review of 100 collision tumors. Int J Surg Pathol. 2018;26:296-305.
5.
KochharSDangSBrownDSchichmanSAduliF. Mantle cell lymphoma involving tubular adenoma: unusual presentation of hematogenous malignancy: 1196. Am J Gastroenterol. 2012;107:S477.
6.
SztarkierILevyIWalfischSDelgadoJBenharrochD. Mantle cell lymphoma in a tubular adenoma: unusual presentation with synchronous colonic carcinoma. Ann Diagn Pathol. 2009;13:47-49.
7.
Handra-LucaA. Diagnostic challenges of composite colorectal tumors of adenoma–mantle cell lymphoma type. Ann Diagn Pathol. 2013;17:544-546.
8.
GenoveseFBecchinaGNagarC, et al. Primary diffuse large B-cell lymphoma developing within a rectal tubular adenoma with low-grade dysplasia: a case report. J Med Case Rep. 2014;8:1-5.
9.
RoebERummelMBlauWEtschmannBGattenlöhnerS. B-cell lymphoma in a tubular adenoma with high-grade dysplasia: a rare extramedullary manifestation of high-grade diffuse large B-cell lymphoma. Endoscopy. 2011;43:E344-E345.
10.
SatoHYasumiKMizunoYIchikawaTHondaKKurodaM. Primary T-cell lymphoma associated with tubulovillous adenoma of the rectum: report of a case. Surg Today. 2013;43:317-320.
11.
LoAAGaoJRaoMSYangGY. Composite Epstein–Barr Virus–associated B-cell lymphoproliferative disorder and tubular adenoma in a rectal polyp. Int J Surg Pathol. 2016;24:73-77.
12.
TakataKOkadaHOhmiyaN, et al. Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity: a multicenter, retrospective analysis in Japan. Cancer Sci. 2011;102:1532-1536.
13.
OverwaterAKesselsKEliasSG, et al. Endoscopic resection of high-risk T1 colorectal carcinoma prior to surgical resection has no adverse effect on long-term outcomes. Gut. 2018;67:284-290.
14.
KusTAktasGKalenderMESariIUlkerECamciC. Collision tumor consisting of primary follicular lymphoma and adenocarcinoma in the cecum: a case report and literature review. Oncol Lett. 2016;11:2801-2805.
15.
LinHHJiangJKLinJK. Collision tumor of low-grade B-cell lymphoma and adenocarcinoma with tuberculosis in the colon: a case report and literature review. World J Surg Oncol. 2014;12:147.
16.
SasakiSHatanakaKSaharaN, et al. Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon: report of a case. Surg Today. 2010;40:975-981.
17.
ShigenoTFujimoriKTsurutaFNozawaYNagayaTMaejimaT. Ileocecal collision tumor composed of adenocarcinoma and primary malignant lymphoma. Clin J Gastroenterol. 2011;4:79-84.
18.
MinatoEFujinoISugihiraNMatsumotoKShimaK. A case of collision tumor of primary malignant lymphoma and poorly-differentiated adenocarcinoma in the ascending colon. Jpn J Gastroenterol Surg. 2004;37:213-216.
19.
ChangHChuangWYShihLYTangTC. Collision in the colon: concurrent adenocarcinoma and diffuse large B-cell lymphoma in the same tumour. Acta Clin Belg. 2011;66:302-304.
20.
JustinRYHuangQHouPLaiJP. Collision tumor of colonic adenocarcinoma and EBV-driven large B-cell lymphoma: a case report and review of literature. Cancer Treat Commun. 2015;3:7-12.
21.
BaoLFengXWangTXingF. Collision tumor of carcinoma and lymphoma in the cecum: case report and review of literature. Int J Clin Exp Pathol. 2020;13:2907.
22.
TsujimotoYCossmanJJaffeECroceCM. Involvement of the Bcl-2 gene in human follicular lymphoma. Science. 1985;228:1440-1443.
23.
IlyasMHaoXPWilkinsonK, et al. Loss of Bcl-2 expression correlates with tumour recurrence in colorectal cancer. Gut. 1998;43:383-387.
