Epithelial-myoepithelial carcinoma (EMCA) is a rare low-grade carcinoma of the salivary glands with multiple morphological variants. One such variant, sebaceous EMCA (SEMCA), has been reported in the literature. Distinguishing it from other tumors such as sebaceous carcinoma is crucial, as SEMCA typically behaves more indolently. We present a case of a SEMCA in the right parotid of a 71-year-old man that shows features of aggressive behavior such as facial nerve invasion and extraparenchymal extension. Also, we report evidence of preexisting pleomorphic adenoma within this tumor.
El-NaggarAKChanJKCGrandisJRTakataTSlootwegPJ. World Health Organization Classification of Tumours. 4th ed.IARC Press; 2017.
2.
DonathKSeifertGSchmitzR. Diagnosis and ultrastructure of the tubular carcinoma of salivary gland ducts. Epithelial-myoepithelial carcinoma of the intercalated ducts [in German]. Virchows Arch A Pathol Pathol Anat. 1972;356:16-31.
3.
SeethalaRRBarnesELHuntJL. Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol. 2007;31:44-57.
4.
SeethalaRRRichmondJAHoscharAPBarnesEL. New variants of epithelial-myoepithelial carcinoma: oncocytic-sebaceous and apocrine. Arch Pathol Lab Med. 2009;133:950-959.
5.
ShinozakiANagaoTEndoH, et al. Sebaceous epithelial-myoepithelial carcinoma of the salivary gland: clinicopathologic and immunohistochemical analysis of 6 cases of a new histologic variant. Am J Surg Pathol. 2008;32:913-923.
6.
StalhammarGElmbergerG. Sebaceous epithelial-myoepithelial carcinoma of the parotid gland: a case report of a new histologic variant. Ann Diagn Pathol. 2014;18:248-252.
7.
LaskiewiczLMirzabeigiMFaquinWLithgowM. Cytologic features of sebaceous epithelial-myoepithelial carcinoma of the salivary gland: a brief report of a rare variant. Diagn Cytopathol. 2015;43:676-679.
8.
SaveraATSalamaME. Oncocytic epithelial-myoepithelial carcinoma of the salivary gland an underrecognized morphologic variant. Mod Pathol. 2005;18(suppl 1):217A.
9.
SeethalaRR. Oncocytic and apocrine epithelial myoepithelial carcinoma: novel variants of a challenging tumor. Head Neck Pathol. 2013;7(suppl 1):S77-S84.
10.
SeethalaRR. Salivary gland tumors: current concepts and controversies. Surg Pathol Clin. 2017;10:155-176.
11.
El HallaniSUdagerAMBellD, et al. Epithelial-myoepithelial carcinoma: frequent morphologic and molecular evidence of preexisting pleomorphic adenoma, common HRAS mutations in PLAG1- intact and HMGA2-intact cases, and occasional TP53, FBXW7, and SMARCB1 alterations in high-grade cases. Am J Surg Pathol. 2018;42:18-27.
