Diffuse-type tenosynovial giant cell tumor can rarely present as an entirely extra-articular mass, which can be misdiagnosed as a sarcoma especially when giant cells are absent, dominated by large dendritic mononuclear cells, and desmin expression is extensive.
SomerhausenNSFletcherCD.Diffuse-type giant cell tumor: clinicopathologic and immunohistochemical analysis of 50 cases with extraarticular disease. Am J Surg Pathol. 2000;24:479-492.
2.
FolpeALWeissSWFletcherCDGownAM.Tenosynovial giant cell tumors: evidence for a desmin-positive dendritic cell subpopulation. Mod Pathol. 1998;11:939-944.
3.
Dal CinPSciotRSamsonIet al. Cytogenetic characterization of tenosynovial giant cell tumors (nodular tenosynovitis). Cancer Res. 1994;54:3986-3987.
4.
SciotRRosaiJDal CinPet al. Analysis of 35 cases of localized and diffuse tenosynovial giant cell tumor: a report from the Chromosomes and Morphology (CHAMP) study group. Mod Pathol. 1999;12:576-579.
5.
WestRBRubinBPMillerMAet al. A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells. Proc Natl Acad Sci U S A. 2006;103:690-695.
