Longstanding/relapsing inflammation characterizing ulcerative colitis (UC) has been associated to an increased risk of colon mucosa neoplastic transformation. We describe the clinicopathological features of a UC-related poorly-differentiated neuroendocrine carcinoma coexisting with a conventional adenocarcinoma. This case supports UC as a multilineage cancerization field.
BolzacchiniEChiniCCortelezziCCet al. Poorly differentiated neuroendocrine carcinoma of the sigmoid tract in long-standing ulcerative colitis: report of a case and review of the literature [published online January 1, 2018]. Int J Surg Pathol. doi:10.1177/1066896917752443.
2.
ShigakiKMitomiHFujimoriTet al. Immunohistochemical analysis of chromogranin A and p53 expressions in ulcerative colitis-associated neoplasia: neuroendocrine differentiation as an early event in the colitis-neoplasia sequence. Hum Pathol. 2013;44:2393-2399.
3.
SaraggiDFassanMMescoliCet al. The molecular landscape of colitis-associated carcinogenesis. Dig Liv Dis. 2017;49:326-330.
