Classic biphasic pulmonary blastoma (CBPB) is a rare and aggressive type of non–small cell lung carcinoma (NSCLC) presenting in adults in the fourth to fifth decade. The prognosis is poor and after surgical resection, therapeutic options are often limited. ROS1 is a proto-oncogene receptor tyrosine kinase that has been identified in some types of NSCLC. We report a case of a 36-year-old woman with CBPB, which was subsequently found to have a ROS1 rearrangement. This is the first reported case of a ROS1-rearranged CBPB. This finding has therapeutic implications as these tumors have the potential to be treated with receptor tyrosine kinase inhibitors.
SmythRJFabreADoddJDBartosikWGallagherCGMcKoneEF.Pulmonary blastoma: a case report and review of the literature. BMC Res Notes. 2014;7:294.
2.
MagistrelliPD’AmbraLBertiSet al. Adult pulmonary blastoma: report of an unusual malignant lung tumor. World J Clin Oncol. 2014;5:1113-1116.
3.
LimanSTAltinokTTopcuSet al. Survival of biphasic pulmonary blastoma. Respir Med. 2006;100:1174-1179.
4.
LarsenHSørensenJB.Pulmonary blastoma: a review with special emphasis on prognosis and treatment. Cancer Treat Rev. 1996;22:145-160.
5.
WeissferdtAMoranCA.Malignant biphasic tumors of the lungs. Adv Anat Pathol. 2011;18:179-189.
6.
ZhaoYYLiuLZhouTet al. A retrospective analysis of the clinicopathological and molecular characteristics of pulmonary blastoma. Onco Targets Ther. 2016;9:6915-6920.
7.
ShawATOuSHIBangYJet al. Crizotinib in ROS1-rearranged non-small-cell lung cancer. N Engl J Med. 2014;371:1963-1971.
8.
PinkelDStraumeTGrayJW.Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. Proc Natl Acad Sci U S A. 1986;83:2934-2938.
9.
SpeicherMRBallardGSWardDC.Karyotyping human chromosomes by combinatorial multi-fluor FISH. Nat Genet. 1996;12:368-375.
10.
AmaravadiRKHamiltonKEMaXet al. Multiple gastrointestinal polyps in patients treated with BRAF inhibitors. Clin Cancer Res. 2015;21:5215-5221.
11.
DaberRSukhadiaSMorrissetteJJD. Understanding the limitations of next generation sequencing informatics, an approach to clinical pipeline validation using artificial data sets. Cancer Genet. 2013;206:441-448.
12.
BarnardWG.Embryoma of lungs. Thorax. 1952;7:299-301.
13.
Van LooSBoeykensEStappaertsIRutsaertR. Classic biphasic pulmonary blastoma: a case report and review of the literature. Lung Cancer. 2011;73:127-132.
14.
NakataniYMiyagiYTakemuraTet al. Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma: beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma. Am J Surg Pathol. 2004;28:921-927.
15.
BodnerSMKossMN.Mutations in the p53 gene in pulmonary blastomas: immunohistochemical and molecular studies. Hum Pathol. 1996;27:1117-1123.
Bosch-BarreraJHolguinFBaldóXet al. Neoadjuvant chemoradiotherapy treatment for a classic biphasic pulmonary blastoma with high PD-L1 expression. Anticancer Res. 2015;35:4871-4875.
18.
GerlingerMRowanAJHorswellSet al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med. 2012;366:883-892.
