We report the case of 55-year-old female with biopsy-proven clear cell renal cell carcinoma with a suspicious lesion found in the liver who presented for right radical nephrectomy and partial hepatectomy. Histologic evaluation of the hepatic specimen demonstrated metastatic renal cell carcinoma within a hepatic hemangioma. Herein we provide a review of the literature for this uncommon scenario.
MaiKTLandryDCRobertsonSJA comparative study of metastatic renal cell carcinoma with correlation to subtype and primary tumor. Pathol Res Pract. 2001;197:671-675.
2.
HoffmannNEGillettMDChevilleJCLohseCMLeibovichBCBluteML. Differences in organ system of distant metastasis by renal cell carcinoma subtype. J Urol. 2008;179:474-477.
3.
XiaGKageyamaYHayashiTKawakamiSYoshidaMKiharaK. Regulation of vascular endothelial growth factor transcription by endothelial PAS domain protein 1 (EPAS1) and possible involvement of EPAS1 in the angiogenesis of renal cell carcinoma. Cancer. 2001;91:1429-1435.
RiniBIRathmellWK. Biological aspects and binding strategies of vascular endothelial growth factor in renal cell carcinoma. Clin Cancer Res. 2007;13:741s-746s.
6.
WheelerYYWheelerGLDiaz-AriasAAAndersRA. Metastatic renal cell carcinoma within a hepatic focal nodular hyperplasia: a case report and review of the literature. Int J Clin Exp Pathol. 2009;2:190-193.
7.
FellegaraGRosaiJ. Multifocal capillary hemangioma-like vascular proliferation of the kidney associated with clear cell renal cell carcinoma: a case report and review of the literature. Int J Surg Pathol. 2013;21:424-426.
8.
ZhangWJYeLYWuLQMorphologic, phenotypic and functional characteristics of endothelial cells derived from human hepatic cavernous hemangioma. J Vasc Res. 2006;43:522-532.
9.
MahajanDMillerCHiroseKMcCulloughAYerianL. Incidental reduction in the size of liver hemangioma following use of VEGF inhibitor bevacizumab. J Hepatol. 2008;49:867-870.