Mixed tumors composed of schwannoma and meningioma are extremely rare and are usually associated with neurofibromatosis type 2. So far, all the cases reported have involved the cerebellopontine angle. Only 3 reported cases did not have a clear association with neurofibromatosis type 2. We report a mixed tumor comprising schwannoma admixed with meningioma and ependymoma in the cervical spinal cord of a 22-year-old male.
KimDGPaekSHChiJGChunYKHanDH. Mixed tumour of schwannoma and meningioma components in a patient with NF-2. Acta Neurochir (Wien). 1997;139:1061-1064.
2.
ElizabethJMenonGNairSRadhakrishnanVV. Mixed tumour of schwannoma and meningioma in a patient with neurofibromatosis-2: a case report. Neurol India. 2001;49:398-400.
3.
GelalFRezankoTUyarogluMATunakanMBezirciogluH. Islets of meningioma in an acoustic schwannoma in a patient with neurofibromatosis-2: pathology and magnetic resonance imaging findings. Acta Radiol. 2005;46:519-522.
4.
DavidoffLMMartinJ. Hereditary combined neurinomas and meningiomas. J Neurosurg. 1955;12:375-384.
5.
GeddesJFSutcliffeJCKingTT. Mixed cranial nerve tumors in neurofibromatosis type 2. Clin Neuropathol. 1995;14:310-313.
6.
LüdemannWStanACTatagibaMSamiiM. Sporadic unilateral vestibular schwannoma with islets of meningioma: case report. Neurosurgery. 2000;47:451-454.
7.
ChenAFSamyRNGantzBJ. Cerebellopontine angle tumor composed of Schwann and meningeal proliferations. Arch Otolaryngol Head Neck Surg. 2001;127:1385-1389.
8.
Al-AnaziAHAl-LuwimiIMShawarbyMAMertolT. Mixed vestibular schwannoma and meningioma without neurofibromatosis. Neurosciences (Riyadh). 2009;14:371-373.
9.
LouisDNOhgakiHWiestlerODCaveneeWK, eds. WHO Classification of Tumors of the Central Nervous System. 4th ed.Lyon, France: IARC Press; 2007:210-214.
10.
EldridgeR. Central neurofibromatosis with bilateral acoustic neuroma. Adv Neurol. 1981;29:57-65.
11.
KanterWREldridgeRFabricantRAllenJCKoerberT. Central neurofibromatosis with bilateral acoustic neuroma: genetic, clinical and biochemical distinctions from peripheral neurofibromatosis. Neurology. 1980;30:851-859.
12.
GoutagnySKalamaridesM. Meningiomas and neurofibromatosis. J Neurooncol. 2010;99:341-347.
13.
RodriguezHABerthrongM. Multiple primary intracranial tumors in von Recklinghausen’s neurofibromatosis. Arch Neurol. 1966;14:467-475.
14.
RusselDRubinsteinL. Tumors and tumor like lesions of maldevelopmental origin. In: Pathology of Tumors of the Nervous System. London, England: Edward Arnold; 1989:693-695.
15.
CushingHEisenhartL. Meningiomas. Their Classification, Regional Behavior, Life History and Surgical End Results. Springfield, IL: Charles C Thomas; 1938:19-55.
16.
KepesJKernohanJW. Meningiomas: problems of histological differential diagnosis. Cancer. 1959;12:364-370.
