Context. A significant portion of colorectal biopsies are performed for evaluation of polyps or polypoid lesions. Accurately identifying these lesions will promote better patient care. Objective. Review of the pathology of major colon polyps and polypoid lesions and highlight the most diagnostically useful features and their molecular biology. Data source. Review of recent literature. Conclusions. Polypoid lesions of the colon can be thought of to be under 3 broad categories: syndromic, mesenchymal, and epithelial.
GreensonJKLampsLWMontgomeryEA. Diagnostic Pathology: Gastrointestinal. 1st ed. Salt Lake City, UT: Amirsys; 2010.
2.
AustDEBarettonGB; Members of the Working Group GI-Pathology of the German Society of Pathology. Serrated polyps of the colon and rectum (hyperplastic polyps, sessile serrated adenomas, traditional serrated adenomas, and mixed polyps)—proposal for diagnostic criteria. Virchows Arch. 2010;457:291-297.
3.
VakianiEYantissRK. Pathologic features and biologic importance of colorectal serrated polyps. Adv Anat Pathol. 2009;16:360-363.
4.
FujitaKYamamotoHMatsumotoT. Sessile serrated adenoma with early neoplastic progression: a clinicopathologic and molecular study. Am J Surg Pathol. 2011;35:295-304.
5.
GoldsteinNS. Serrated pathway and APC (conventional)-type colorectal polyps: molecular-morphologic correlations, genetic pathways, and implications for classification. Am J Clin Pathol. 2006;125:146-153.
6.
KimKMLeeEJHaS. Molecular features of colorectal hyperplastic polyps and sessile serrated adenoma/polyps from Korea. Am J Surg Pathol. 2011;35: 1274-1286.
7.
MontgomeryE. Colorectal polyps: sporadic and syndromic. Int J Surg Pathol. 2010;18(3 suppl):56S-61S.
8.
OlschwangSMarkieDSealS. Peutz-Jeghers disease: most, but not all, families are compatible with linkage to 19p13.3. J Med Genet. 1998;35:42-44.
9.
Eslami-VarzanehFWashingtonKRobertMEKashgarianMGoldblumJRJainD. Benign fibroblastic polyps of the colon: a histologic, immunohistochemical and ultrastructural study. Am J Surg Pathol. 2004;28:374-378.
10.
RittershausACAppelmanHD. Benign gastrointestinal mesenchymal BUMPs. A brief review of some spindle cell polyps with published names. Arch Pathol Lab Med. 2011;135:1311-1319.
11.
HornickJLFletcherCD. Intestinal perineuriomas: clinicopathologic definition of a new anatomic subset in a series of 10 cases. Am J Surg Pathol. 2005;29:859-865.
12.
ChanOTHaghighiP. Hamartomatous polyps of the colon: ganglioneuromatous, stromal, and lipomatous. Arch Pathol Lab Med. 2006;130:1561-1566.
13.
MiettinenMSarlomo-RikalaMSobinLH. Mesenchymal tumors of muscularis mucosae of colon and rectum are benign leiomyomas that should be separated from gastrointestinal stromal tumors. A clinicopathologic and immunohistochemical study of eighty-eight cases. Mod Pathol. 2001;14:950-956.
14.
IshigakiHTanakaMNaritaT. Fibrovascular polyp of the sigmoid colon. J Gastroenterol. 1994;29:763-766.
15.
RossiGBde BellisMMaronePDe ChiaraALositoSTempestaA. Granular cell tumors of the colon: report of a case and review of the literature. J Clin Gastroenterol. 2000;30:197-199.
16.
ZhangHCongJCChenCSQiaoLLiuEQ. Submucous colon lipoma: a case report and review of the literature. World J Gastroenterol. 2005;11:3167-3169.
17.
LevyADAbbottRMRohrmannCRJrFrazierLLKendeA. Gastrointestinal hemangiomas: imaging findings with pathologic correlation in pediatric and adult patients. AJR Am J Roentgenol. 2001;17:1073-1081.
18.
LeeJMChungWCLeeKM. Spontaneous resolution of multiple lymphangiomas of the colon: a case report. World J Gastroenterol. 2011;17:1515-1518.
19.
NakasonoMHirokawaMMugurumaN. Colorectal xanthomas with polypoid lesion: report of 25 cases. APMIS. 2004;112:3-10.
20.
De PetrisGLeungST. Pseudoneoplasms of the gastrointestinal tract. Arch Pathol Lab Med. 2010;134:378-392.
21.
OdzeRDGoldblumJR. Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas. 2nd ed.Philadelphia, PA: Saunders Elsevier; 2009.
