Involvement of the tongue by a synovial sarcoma (SS) is an extremely rare event; there have only been 13 cases previously reported. The authors present herein a case of monophasic SS arising in the tongue in a 32-year-old woman. The neoplasm expressed cytokeratins AE1-3, OSCAR, and EMA as well as Bcl-2 and TLE1. Molecular analysis indicated that the patient tested positive for the SYT/SS2 fusion transcript.
de Almeida-LawallMMosqueda-TaylorABologna-MolinaRE. Synovial sarcoma of the tongue: case report and review of the literature. J Oral Maxillofac Surg. 2009;98:914-920.
4.
AgarwalAPShetTMJoshiRDesaiSBChinoyRF. Monophasic synovial sarcoma of the tongue. Indian J Pathol Microbiol. 2010;52;568-570.
5.
WangHZhangJXing HeXNiuY. Synovial sarcoma in the oral and maxillofacial region: report of 4 cases and review of the literature. J Oral Maxillofac Surg. 2008;66: 161-167.
MeerSColemanHAltiniM. Oral synovial sarcoma: a report of 2 cases and a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;93:306-315.
8.
ShmooklerBMEnzingerFMBrannonRB. Orofacial synovial sarcoma: a clinicopathologic study of 11 new cases and review of the literature. Cancer. 1982;50:200-269.
9.
AmeerallyPJSiraSKBarrettAWHollowsP. Synovial sarcoma of the hard palate. Br J Oral Maxillofac Surg. 2004;42:261-263.
10.
MassarelliGTandaFSalisB. Synovial sarcoma of the soft palate. Hum Pathol. 1978;9:341-345.
11.
CarrilloREl-nagarAKRodríguez-PeraltoJLBatsakisJG. Synovial sarcoma of the tongue: case report and review of the literature. J Oral Maxillofac Surg. 1992;50:904-906.
12.
KomisCLagogiannisGAFaratzisGRapidisAD. Synovial sarcoma of the tongue: report of a case and review of the literature. J Oral Maxillofac Surg. 2008;66:154-160.
13.
Mir-AbedyM. Considerations on the base of the tongue and its tumors (a propos of a case of synovial sarcoma and a case of neurofibroma). Ann Otolaryngol Chir Cervicofac. 1962;79:547-601.
14.
FisherC. Synovial sarcoma: ultrastructural and immunohistochemical features of epithelial differentiation in monophasic and biphasic tumors. Hum Pathol. 1986;17:996-1002.
15.
FisherC. Synovial sarcoma. Ann Diagn Pathol. 1998;2:401-421.
JagdisARubinBTubbsRRPachecoMNielsenTO. Prospective evaluation of TLE1 as a diagnostic immunohistochemical marker in synovial sarcoma. Am J Surg Pathol. 2009;33:1743-1751.
18.
FragaMFBardascoMBallesterE. Epigenetic inactivation of the Groucho Homologue TLE1 in hematologic malignancies. Cancer Res. 2008;68:4116-4122.
19.
KosemehmetogluKVranaJAFolpeAL. TLE1 expression is not specific for sinovial sarcoma: a whole section study of 163 soft tissue and bone neoplasms. Mod Pathol. 2009;22:872-878.
20.
PrettoDBarcoRRiveraJ. The synovial sarcoma translocation protein SYT-SSX2 recruits beta-catenin to the nucleus and associates with it in an active complex. Oncogene. 2006;25:9226-9235.
21.
CoindreJ-MPelmusMHosteinILussanCBuiBHGuillouL. Should molecular testing be required for diagnosing synovial sarcoma?. Cancer. 2003;98:2700-2707.
