Adenohibernoma of the breast is a very rare tumor composed of brown fat tissue and intermingled glandular tissue. There are only 2 case reports in literature. This study reports the third case of adenohibernoma of the breast, which is not accompanied by breast cancer differing from the previous cases. And, to the best of the authors’ knowledge, this is also the first case of adenohibernoma of the breast that has demonstrated adipophilin expression immunohistochemically.
FurlongMAFanburg-SmithJCMiettinenM. The morphologic spectrum of hibernoma. A clinicopathologic study of 170 cases. Am J Surg Pathol. 2001;25:809-814.
5.
ColvilleJFeiginKTangLKeatingDCohenMA. Mammary hibernoma. Breast J. 2006;12:563-565.
6.
MartiniNLonderoVMachinP. An unusual breast lesion: the ultrasonographic, mammographic, MRI and nuclear medicine findings of mammary hibernoma. Br J Radiol. 2010;83:e1-e4.
7.
Padilla-RodriguezAL. Pure hibernoma of the breast: insights about its origins [published online ahead of print May 3, 2011]. Ann Diagn Pathol. doi:10.1016/j.anndiagpath.2011.01.00410.1016/j.anndiagpath.2011.01.004
8.
GarijoMFTorioBVal-BernalJF. Mammary hamartoma with brown adipose tissue. Gen Diagn Pathol. 1997;143:243-246.
9.
OstlerDAPrietoVGReedJADeaversMTLazarAJIvanD. Adipophilin expression in sebaceous tumors and other cutaneous lesions with clear cell histology: an immunohistochemical study of 117 cases. Mod Pathol. 2010;23:567-573.
10.
HeidHWMollRSchwetlickIRacktwitzHRKeenanTW. Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases. Cell Tissue Res. 1998; 294: 309-321.