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Abstract

This report describes a 60-year-old man with concurrent gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) and classical Hodgkin lymphoma (CHL). Atypical, medium-sized, lymphoid cells proliferated in the mucosa to muscular layer of the stomach showing a lymphoepithelial lesion; admixed with Hodgkin/Reed-Sternberg (HRS) cells and an inflammatory cell background. MALT lymphoma cells expressed CD20, CD79a, PAX5, and BOB.1, and HRS cells expressed CD30, CD15, Epstein–Barr virus–encoded RNA, and EBV-latent membrane protein 1. Only CHL invaded into the regional lymph nodes. Two possibilities of transformation of MALT lymphoma into CHL and de novo CHL within MALT lymphoma are discussed.

Keywords

concurrent lymphoma gastric MALT classical Hodgkin lymphoma Epstein–Barr virus infection transformation composite lymphoma de novo lymphoma

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References

Chan

JKC

. Tumors of the lymphoreticular system, including spleen and thymus. In: Fletcher

CDM

, ed. Diagnostic Histopathology of Tumors. 2nd ed. London, UK: Churchill Livingstone; 2000:1099-1245.

Stein

Delsol

Pileri

Weiss

Poppema

Jaffe

. Classical Hodgkin lymphoma, introduction. In: Swerdlow

Campo

Harris

. eds. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon, France: IARC Press; 2008:326-334.

Hossain

Koak

Khan

. Primary gastric Hodgkin’s lymphoma. World J Surg Oncol. 2007;5:119-121.

Isaacson

Chott

Nakamura

Müller-Hermelink

Harris

Swerdlow

. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In: Swerdlow

Campo

Harris

. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th ed. Lyon, France: IARC Press; 2008:214-217.

Chan

JKC

Isaacson

. Relationship between high-grade lymphoma and low-grade B-cell mucosa-associated lymphoid tissue lymphoma (MALToma) of the stomach. Am J Pathol. 1990;136:1153-1164.

Ioachim

. Composite lymphoma. In: Ioachim

, ed. Lymph Node Pathology. 2nd ed. Philadelphia, PA: JB Lippincott; 1994:488-490.

Aguilera

Howard

Brissette

Abbondanzo

. Hodgkin’s disease and an extranodal marginal zone B-cell lymphoma in the small intestine: an unusual composite lymphoma. Mod Pathol. 1996;9:1020-1026.

Zettl

Rüdiger

Marx

Müller-Hermelink

Ott

. Composite marginal zone B-cell lymphoma and classical Hodgkin’s lymphoma: a clinicopathological study of 12 cases. Histopathology. 2005;46:217-228.

Harada

Kalla

Balasubramanian

Brodsky

Gladstone

Hou

. Classical Hodgkin lymphoma concurrently evolving in a patient with marginal zone B-cell lymphoma of the spleen. Ann Diagn Pathol. 2008;12:212-216.

10.

Fung

Neuhauser

Thompson

. Hodgkin-like transformation of a marginal zone B-cell lymphoma of the larynx. Ann Diagn Pathol. 2002;6:61-66.

11.

Rosenquist

Roos

Erlanson

Küppers

Bräuninger

Hansmann

. Clonally related splenic marginal zone lymphoma and Hodgkin lymphoma with unmutated V gene rearrangement and a 15-yr time gap between diagnosis. Eur J Haematol. 2004;73:210-214.

12.

Shimizu

Hara

Yatabe

. Hodgkin’s disease following extranodal marginal zone B-cell lymphoma in remission. Int J Hematol. 1999;69:96-100.

13.

Oka

Shinonaga

Nagayama

. Coexistence of primary pulmonary Hodgkin lymphoma and gastric MALT lymphoma associated with Epstein-Barr virus infection: a case report. Pathol Int. 2010;60:520-523.

14.

Guarner

del Rio

Hendrix

Unger

. Composite Hodgkin’s and non-Hodgkin’s lymphoma in a patient with acquired immune deficiency syndrome. In-situ demonstration of Epstein-Barr virus. Cancer. 1990;66:796-800.

Concurrent Gastric MALT and Hodgkin Lymphoma

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