A case is reported of an intra-abdominal desmoplastic small cell tumor featuring giant bizarre nuclei, an event not previously recorded in this entity to the best of the authors’ knowledge. The diagnosis was confirmed by immunohistochemistry and molecular genetics. A list is provided of the many other conditions in which this morphologically spectacular but clinically inconsequential nuclear change has been recorded.
GeraldWLMillerHKBattiforaHMiettinenMSilvaEGRosaiJ. Intra-abdominal desmoplastic small round-cell tumor. Report of 19 cases of a distinctive type of high-grade polyphenotypic malignancy affecting young individuals. Am J Surg Pathol. 1991;15:499-513.
2.
FriedrichsNTestiMAMoiraghiL. Clear cell sarcoma-like tumor with osteoclast-like cells in the small bowel: further evidence for a new tumor entity. Int J Surg Pathol. 2005;13:313-318.
3.
OrdoñezNG. Desmoplastic small round cell tumor: I: a histopathologic study of 39 cases with emphasis on unusual histological patterns. Am J Surg Pathol. 1998;22:1303-1313.
4.
WeidnerNAskinFBBerthrongMHopkinsMBKuteTEMcGuirtFW. Bizarre (pseudomalignant) granulation-tissue reactions following ionizing-radiation exposure. A microscopic, immunohistochemical, and flow-cytometric study. Cancer. 1987;59:1509-1514.
5.
CarcangiuMLSteeperTZampiGRosaiJ. Anaplastic thyroid carcinoma. A study of 70 cases. Am J Clin Pathol. 1985;83:135-158.
KaminoHLeeJYBerkeA. Pleomorphic fibroma of the skin: a benign neoplasm with cytologic atypia. A clinicopathologic study of eight cases. Am J Surg Pathol. 1989;13: 107-113.
11.
GoodmanWTBangRHPadillaRS. Giant dermatofibroma with monster cells. Am J Dermatopathol. 2002;24:36-38.
12.
TamadaSAckermanAB. Dermatofibroma with monster cells. Am J Dermatopathol. 1987;9:380-387.
13.
LamovecJBrackoMVoncinaD. Pleomorphic fibroma of tendon sheath. Am J Surg Pathol. 1991;15:1202-1205.
14.
BrooksJJWellsGBYehITLiVolsiVA. Bizarre epithelioid lipoleiomyoma of the uterus. Int J Gynecol Pathol. 1992;11:144-149.
15.
DownesKAHartWR. Bizarre leiomyomas of the uterus: a comprehensive pathologic study of 24 cases with long-term follow-up. Am J Surg Pathol. 1997;21:1261-1270.
16.
SloneSO’ConnorD. Scrotal leiomyomas with bizarre nuclei: a report of three cases. Mod Pathol. 1998;11:282-287.
TaiLHTavassoliFA. Endometrial polyps with atypical (bizarre) stromal cells. Am J Surg Pathol. 2002;26:505-509.
19.
ShahRMcCluggageWG. Symplastic atypia in neoplastic and non-neoplastic endometrial stroma: report of 3 cases with a review of atypical symplastic cells within the female genital tract. Int J Gynecol Pathol. 2009;28:334-337.
20.
StewartCJLeungYCMathewRMcCartneyAL. Extrauterine adenomyoma with atypical (symplastic) smooth muscle cells: a report of 2 cases. Int J Gynecol Pathol. 2009;28:23-28.
21.
CarlàTGFiloticoRFiloticoM. Bizarre angiomyomas of superficial soft tissues. Pathologica. 1991;83:237-242.
22.
ChongYEomMMinHJKimSChungYKLeeKG. Symplastic glomus tumor: a case report. Am J Dermatopathol. 2009;31:71-73.
23.
PrasadMLKeatingJPTeohHH. Pleomorphic angiomyolipoma of digestive tract: a heretofore unrecognized entity. Int J Surg Pathol. 2000;8:67-72.
24.
FolpeALWeissSW. Pleomorphic hyalinizing angiectatic tumor: analysis of 41 cases supporting evolution from a distinctive precursor lesion. Am J Surg Pathol. 2004;28:1417-1425.
25.
GaffeyMJFriersonHFJrIezzoniJC. Ovarian granulosa cell tumors with bizarre nuclei: an immunohistochemical analysis with fluorescence in situ hybridization documenting trisomy 12 in the bizarre component. Mod Pathol. 1996;9:308-315.
26.
YoungRHScullyRE. Ovarian sex cord-stromal tumors with bizarre nuclei: a clinicopathologic analysis of 17 cases. Int J Gynecol Pathol. 1983;1:325-335.
CheukWLeeAKAroraNBen-ArieYChanJK. Splenic hamartoma with bizarre stromal cells. Am J Surg Pathol. 2005;29:109-114.
29.
SerraSChettyR. Bizarre stromal cells in ischemic bowel disease. Ann Diagn Pathol. 2005;9:193-196.
30.
ShekitkaKMHelwigEB. Deceptive bizarre stromal cells in polyps and ulcers of the gastrointestinal tract. Cancer. 1991;67:2111-2117.
31.
GhosseinRARosaiJHeffessC. Dyshormogenetic goiter: a clinicopathologic study of 56 cases. Endocr Pathol. 1997;8:283-292.
32.
SchantzACastlemanB. Parathyroid carcinoma. A study of 70 cases. Cancer. 1973;31:600-605.
33.
WeissLM. Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors. Am J Surg Pathol. 1984;8:163-169.
34.
McNicolAM. Histopathology and immunohistochemistry of adrenal medullary tumors and paragangliomas. Endocr Pathol. 2006;17:329-336.
35.
KuoTGomezLG. Monstrous epithelial cells in human epididymis and seminal vesicles. A pseudomalignant change. Am J Surg Pathol. 1981;5:483-490.
36.
TakedaY. An immunohistochemical study of bizarre neoplastic cells in pleomorphic adenoma: its cytological nature and proliferative activity. Pathol Int. 1999;49:993-999.
