Low-Grade Ductal Carcinoma In Situ and Invasive Mammary Carcinoma With Columnar Cell Morphology Arising in a Complex Fibroadenoma in Continuity With Columnar Cell Change and Flat Epithelial Atypia

Abstract

We describe the clinicopathologic features of a small low-grade invasive mammary carcinoma with cytomorphological columnar cell features arising in a complex fibroadenoma that in addition to sclerosing adenosis, apocrine metaplasia, and usual ductal hyperplasia also displayed columnar cell change with flat epithelial atypia and low-grade ductal carcinoma in situ merging with the invasive carcinoma. There were strong cytomorphological similarities between the invasive carcinoma and the low-grade ductal carcinoma in situ, which also showed significant overlap in the immunohistochemical findings.

Keywords

carcinoma fibroadenoma flat epithelial atypia columnar cell change columnar cell atypia

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