The authors describe the case of a 36-year-old man with gynecomastia who was previously treated with liposuction of the breast for cosmetic purposes. Histologic examination of a subsequent excisional biopsy revealed nests of displaced epithelial cells in adipose tissue. Epithelial cell displacement is a well-known risk of core needle biopsies and fine-needle aspirations of breast lesions. However, to the authors’ knowledge, epithelial displacement in gynecomastia after liposuction, mimicking invasive ductal carcinoma, has not previously been reported.
RosenPR. Rosen’s Breast Pathology. 3rd ed.Philadelphia, PA: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2009.
2.
KumarVAbbasAKFaustoN. Robbins and Cotran’s Pathologic Basis of Disease. 7th ed.Philadelphia, PA: Elsevier Saunders; 2005.
3.
NarulaHSCarlsonHE. Gynecomastia. Endocrinol Metab Clin North Am. 2007;36:497-519.
4.
WilliamsMJ. Gynecomastia: its incidence, recognition and host characterization in 447 autopsy cases. Am J Med. 1963;34:103-112.
5.
AndersenJAGramJB. Gynecomasty: histological aspects in a surgical material. Acta Pathol Microbiol Immunol Scand A. 1982;90:185-190.
6.
NicolisGLModlingerRSGabriloveJL. A study of the histopathology of human gynecomastia. J Clin Endocrinol Metab. 1971;32:173-178.
7.
NagiCBleiweissIJafferS. Epithelial displacement in breast lesions: a papillary phenomenon. Arch Pathol Lab Med. 2005;129:1465-1469.
8.
PhelanSO’DohertyAHillAQuinnCM. Epithelial displacement during breast needle core biopsy causes diagnostic difficulties in subsequent surgical excision specimens. J Clin Pathol. 2007;60:373-376.
9.
YoungsonBJCranorMRosenPP. Epithelial displacement in surgical breast specimens following needling procedures. Am J Surg Pathol. 1994;18:896-903.
10.
ChunJTTaylorJWVan MeterSE. Histologic changes with breast ultrasound-assisted liposuction. In: ShiffmanMADi GiuseppeA, eds. Liposuction: Principles and Practice. New York, NY: Springer; 2006:258-261.
11.
LeeKCChanJKHoLC. Histologic changes in the breast after fine-needle aspiration. Am J Surg Pathol. 1994;18:1039-1047.
12.
YoungsonBJLibermanLRosenPP. Displacement of carcinomatous epithelium in surgical breast specimens following stereotaxic core biopsy. Am J Clin Pathol. 1995;103:598-602.
13.
DiazLKWileyELVentaLA. Are malignant cells displaced by large-gauge needle core biopsy of the breast?AJR Am J Roentgenol. 1999;173:1303-1313.
14.
Douglas-JonesAGVergheseA. Diagnostic difficulty arising from displaced epithelium after core biopsy in intracystic papillary lesions of the breast. J Clin Pathol. 2002;55:780-783.
15.
ChauYPChanJKC. Fine-needle-aspiration-induced histologic changes. Current Diag Pathol. 2003;9:78-88.
