Nest-like structures are the cardinal lesion of different benign and malignant bladder entities. These entities emphasize the biological relevance of the subtle morphological nest plasticity. The authors present 25 benign and malignant neoplasms, sharing the presence of florid nest-like growth and the scarcity or absence of superficial papillary components. Differential diagnostic clues are discussed.
Eble JN, Sauter G., Epstein JI, et al. Infiltrating urothelial carcinoma. In: WHO Pathology and Genetics of Tumors of the Urinary System and Male Genital Tract. Lyon, France: IARC Press; 2004: 93-109.
Talbert ML, Young RHCarcinomas of the urinary bladder with deceptively benign-appearing foci. A report of three cases. Am J Surg Pathol. 1989;13:374-381.
5.
Murphy WM, Deana DGThe nested variant of transitional cell carcinoma: a neoplasm resembling proliferation of Brunn’s nests. Mod Pathol. 1992;5:240-243.
6.
Drew PA, Furman J., Civantos F., Murphy WMThe nested variant of transitional cell carcinoma: an aggressive neoplasm with innocuous histology. Mod Pathol. 1996 ;9:989-994.
7.
Lin O., Cardillo M., Dalbagni, Linkov I, Hutchinson B., Reuter VENested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 12 cases. Mod Pathol. 2003;16:1289-1298.
8.
Nigwekar P., Amin MBThe many faces of urothelial carcinoma: an update with an emphasis on recently described variants. Adv Anat Pathol. 2008;15:218-233.
9.
Amin MB, Gómez JA, Young RHUrothelial transitional cell carcinoma with endophytic growth patterns: a discussion of patterns of invasion and problems associated with assessment of invasion in 18 cases. Am J Surg Pathol. 1997;21: 1057-1068.
10.
Jones TD, Zhang S., Lopez-Beltran A., et al. Urothelial carcinoma with an inverted growth pattern can be distinguished from inverted papilloma by fluorescence in situ hybridization, immunohistochemistry,and morphologic analysis. Am J Surg Pathol . 2007;31:1861-1867.
11.
Volmar KE, Chan TY, De Marzo AM, Epstein JIFlorid von Brunn nests mimicking urothelial carcinoma: a morphologic and immunohistochemical comparison to the nested variant of urothelial carcinoma. Am J Surg Pathol. 2003;27: 1243-1252.
12.
Dhall D., Al-Ahmadie H., Olgac S.Nested variant of urothelial carcinoma. Arch Pathol Lab Med . 2007;131:1725-1727.
13.
Cheng L., Leibovich B., Cheville JC, et al. Paranganglioma of the urinary bladder. Cancer . 2000;88:844-852.
14.
Leroy X., Leteurtre E., De La Taille A., Augusto D., Biserte J., Gosselin B.Microcystic transitional cell carcinoma: a report of 2 cases arising in the renal pelvis. Arch Pathol Lab Med. 2002;126:859-861.
15.
Young R., Oliva E.Transitional cell carcinoma of the urinary bladder that may be underdiagnosed: a report of four invasive cases exemplifying the homology between neoplastic and non-neoplastic transitional cell lesions. Am J Surg Pathol . 1996;20:1448-1454.
16.
Sung MT, Eble JN, Wang M., Tan PH, Lopez-Beltran A., Cheng L.Inverted papilloma of the urinary bladder: a molecular genetic appraisal. Mod Pathol. 2006;19:1289-1294.
17.
Kunze E., Schauer A., Schmitt M.Histology and histogenenesis of two different types of inverted urothelial papillomas. Cancer. 1983;51:348-358.
18.
Montironi R. , Lopez-Beltran A., Scarpelli M., Mazzucchelli R., Cheng L.Morphologic classification and definition of benign, preneoplastic and noninvasive neoplastic lesions of the urinary bladder. Histopathology. 2008;53:621-631.
19.
Lopez-Beltran A., Cheng L.Histologic variants of urothelial carcinoma: differential diagnosis and clinical implications. Hum Pathol . 2006;37:1371-1388.
20.
Patriarca C., Giunta P.Are invasive micropapillary carcinoma of breast really composed of micropapillae ? Int J Surg Pathol. 2009;17:354
21.
Nassar H., Pansare V., Zhang H., et al. Pathogenesis of invasive micropapillary carcinoma: role of MUC1 glycoprotein. Mod Pathol. 2004;17:1045-1050.
22.
Lotan TL, Ye H., Melamed J., Wu XR, Shih IM, Epstein JIImmunohistochemical panel to identify the primary site of invasive micropapillary carcinoma. Am J Surg Pathol. 2009;33:1037-1041.
23.
Samaratunga H., Khoo K.Micropapillary variant of urothelial carcinoma of the urinary bladder: a clinicopathological and immunohistochemical study . Histopathology. 2004;45: 45-54.
24.
McKenney JKThe clinical management of "superficial" (pT1/cT1) micropapillary carcinoma of the urinary bladder: are times changing? Adv Anat Pathol. 2007;14:444-445.