Juvenile granulosa cell tumor of the testis of neonates and infants is an uncommon lesion frequently associated with abnormal sex chromosome and ambiguous genitalia. This report describes a juvenile granulosa cell tumor arising in the testis of a neonate. Chromosome analysis of the tumor showed a normal male karyotype 46 XY. Histopathology and immunohistochemical studies revealed the occurrence of 2 well-differentiated epithelial-like and smooth muscle-like components in the neoplasm. The morphologic clues leading to the correct diagnosis of juvenile granulosa cell tumor and the possible histogenesis are briefly discussed.
Kos M., Nogaless FF, Stipoljev F., Kunjko K.Congenital juvenile granulosa cell tumor of the testis in a testis showing full 69, XXY triploidy. Int J Surg Pathol. 2005; 13:219-221.
2.
Nieto N., Torres-Valdivieso MJ, Aguado P., et al. Juvenile granulosa cell tumor of the testis: case report and review of the literature. Tumori. 2002;88:72-74.
3.
Raju U., Fine G., Warrier R., Kini R., Weiss L.Congenital testicular juvenile granulosa Cell tumor in a neonate with X/XY mosaicism. Am J Surg Pathol. 1986;10:577-583.
4.
Schofield DE , Fletcher JATrisomy 12 in pediatric granulose-stromal cell tumors. Demonstration by a modified method of fluorescence in situ hybridization on paraffin-embedded material. Am J Surg Pathol. 1992; 141:1265-1269.
5.
Tanaka Y., Sasaki Y., Tachibana K., Suwa S., Terashima K., Nakatani Y.Testicular juvenile granulosa cell tumor in an infant with X/XY mosaicism clinically diagnosed as true hermaphroditism. Am J Surg Pathol . 1994;18:316-322.
6.
Chan JK, Chan VS, Mak KLCongenital juvenile granulosa cell tumor of the testis: report of a case showing extensive degenerative changes. Histopathology. 1990;17: 75-80.
7.
Ross JH, Rybicki L., Kay R.Clinical behavior and a contemporary management algorithm for prepubertal testis tumors: a summary of the prepubertal testis tumor registry. J Urol.2002;168:1675-1679.
8.
Shukla AR, Huff DS, Canning DA, et al. Juvenile granulosa cell tumor of the testis: contemporary clinical management and pathological diagnosis. J Urol.2004;171: 1900-1902.
9.
Young RHSex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. Mod Pathol.2005;18(suppl 2): 81-98.
10.
Renshaw AA, Gordon M., Corless CLImmunohistochemistry of unclassified sex cord-stromal tumors of the testis with a predominance of spindle cells. Mod Pathol. 1997:10:693-700.
11.
Broshears JR , Roth LMGynandroblastoma with elements resembling juvenile granulosa cell tumor. Int J Gynecol Pathol. 1997;16:387-391.
12.
Cools M., Stoop H., Kersemaekers A-MF, et al. Gonadoblastoma arising in undifferentiated gonadal tissue within dysgenetic gonads. J Clin Endocrinol Metab.2006;91: 2404-2413.
13.
Hatano T., Yoshino Y., Kawashimi Y., et al. Case of gonadoblastoma in a 9-year-old boy without physical abnormalities. Int J Urol.1999;6:164-166.
14.
Nistal M., Redondo E., Paniagua R.Juvenile granulosa cell tumor of the testis. Arch Pathol Lab Med.1988;112: 1129-1132.
15.
Pinto MMJuvenile granulosa cell tumor of the infant testis: case report with ultrastructural observations. Pediatr Pathol.1985;4:277-289.
16.
Groisman GM , Dische MR, Fine EM, Unger PDJuvenile granulosa cell tumor of the testis: a comparative immunohistochemical study with normal infantile gonads. Pediatr Pathol.1993;13:389-400.
