Yolk sac tumor (endodermal sinus tumor) is a malignant germ cell tumor that usually arises in the gonads. Extragonadal germ cell tumors are rare and have been described in case reports. We report a pure intrarenal yolk sac tumor in a 1-year-old boy who presented with a huge abdominal mass and was operated for suspected Wilms tumor. The tumor exhibited histopathologic and immunohistochemical features identical to those of an endodermal sinus tumor of gonadal origin. The purpose of this report is to add a rare tumor to the differential diagnosis of pediatric renal neoplasms.
Huang HY, Ko SF, Chuang JH, Jeng YM, Sung MT, Chen WJPrimary yolk sac tumor of the urachus. Arch Pathol Lab Med.2002;126:1106-1109.
2.
Dehner LPIntrarenal teratoma occurring in infancy: report of a case with discussion of extragonadal germ cell tumors in infancy. J Pediat S.1973;8:369-378.
3.
Xinghui Y., Jing H., Mingju L., Weizhong G.Endodermal sinus tumour of the omentum in a child. Pediatr Radiol.2004;34:985-987.
4.
Namiki K., Tsuchiya A., Noda K., et al. Extragonadal germ cell tumor of the prostate associated with Klinefelter's syndrome. Int J Urol.1999;6:158-161.
5.
Deshmukh C., Bakshi A., Bhagwat R., Kurkure P.Yolk sac tumor of vagina. Indian J Pediatr.2005;72:367.
6.
Penkar SJ, Irani S., Prabhu VL, Candes FP, Nimbkar SAEndodermal sinus tumor of vulva (a case report). J Postgrad Med.1992;38:44-45.
7.
Mufti T., Khan M.S., Dua M.U. and Waqar F.Malignant sacrococcygeal yolk sac (endodermal sinus) tumor. J Ayub Med Coll.2002;14:28-30.
8.
Suzuki T., Kimura N., Shizawa S., et al. Yolk sac tumor of the stomach with an adenocarcinomatous component: a case report with immunohistochemical analysis. Pathol Int . 1999;49:557-562.
9.
Nishio S., Fukui M., Iwaki T., Morioka T., Kitamura K.Primary pineal yolk sac tumor: ultrastructural and immunohistochemical features—case report. Neurol Med Chir (Tokyo). 1986;26:564-570.
10.
Natori T., Teshima S., Kikuchi Y., et al. Primary yolk sac tumor of the liver. An autopsy case with ultrastructural and immunopathological studies. Acta Pathol Jpn. 1983;33:555-564.
11.
Liu Y., Wang J., Chen C., Sung P., Tseng H.Intrarenal mixed germ cell tumor. J Urol.2000;164:2020-2221.
12.
Radhika S., Bakshi A., Rajwanshi A., et al. Cytopathology of uncommon malignant renal neoplasms in the pediatric age group. Diagn Cytopathol. 2005;32:281-286.
13.
Brown NJTeratomas and yolk-sac tumours. J Clin Pathol.1976;29:1021-1025.
