Chondromatous hamartoma of the chest wall is an extremely rare, benign lesion that usually occurs in early infancy. It typically arises in the rib cage and produces a large mass. It is composed of a varying admixture of hyaline cartilage that has features resembling growth plate cartilage, fascicles of spindle cells, woven bone, and hemorrhagic cysts. Treatment consists mainly of surgical excision, which is usually curative. We present 3 new cases, which demonstrated interesting findings, including multicentricity, involvement of the sternum, and local recurrence, and we discuss these findings in the context of a literature review.
McLeod RA, Dahlin DC. Hamartoma (mesenchymoma) of the chest wall in infancy. Radiology131:657–661, 1979
2.
Cohen MC, Drut R, Garcia C, Kaschula RO. Mesenchymal hamartoma of the chest wall: A cooperative study with review of the literature. Pediatr Pathol12:525–534, 1992
3.
Ayala AG, Ro JY, Bolio-Solis A, Hernandez-Batres F, Eftekhari F, Edeiken J. Mesenchymal hamartoma of the chest wall in infants and children: A clinicopathological study of five patients. Skeletal Radiol22:569–576, 1993
4.
Groom KR, Murphey MD, Howard LM, Lonergan GJ, Rosado-De-Christenson ML, Torop AH. Mesenchymal hamartoma of the chest wall: Radiologic manifestations with emphasis on cross-sectional imaging and histopathologic comparison. Radiology222:205–211, 2002.
5.
Kim JY, Jung WH, Yoon CS, Kim MJ, Kim HK, Kim KD, Cho SH. Mesenchymal hamartomas of the chest wall in infancy: Radiologic and pathologic correlation. Yonsei Med J41:615–622, 2000
6.
Rao L, Kini AC, Valiathan M, Gurpur CR, Rao RV. Infantile cartilaginous hamartoma of the rib. A case report. Acta Cytol45:69–73, 2001
7.
Hall DP, Ellison RG. Osteochondrosarcoma of the Chest Wall in a Newborn Infant: A Case Report Six Years after Surgery. Am Surg30:745–747, 1964.
8.
Hopkins SM, Freitas EL. Bilateral Osteochondroma of the Ribs in an Infant: An Unusual Cause of Cyanosis. J Thorac Cardiovasc Surg49:247–249, 1965
9.
Seibert J, Rossi N, McCarthy E. A primary rib tumor in a newborn. Pediatr Surg11:1331–1332, 1976
10.
Kadell BM, Coulson WF, Desilets DT, Fonkalsrud EW. Congenital atypical benign chondroblastoma of a rib. J Pediatr Surg5:46–52, 1970
11.
Le Ber M. Benign mesenchymomas in children. Cancer15:598–605, 1962
12.
Blumenthal BI, Capitanio MA, Queloz JM, Kirkpatrick JA. Intrathoracic mesenchymoma. Observations in two infants. Radiology104:107–109, 1972
13.
Campbell AN, Wagget J, Mott MG. Benign mesenchymoma of the chest wall in infancy. J Surg Oncol21:267–270, 1982
14.
Oakley RH, Carty H, Cudmore RE. Multiple benign mesenchymomata of the chest wall. Pediatr Radiol15:58–60, 1985
15.
Eskelinen M, Kosma VM, Vainio J. Mesenchymoma of the chest wall in children. Ann Thorac Surg52:291–293, 1991
16.
Mayer CM, Favara BE, Holton CP, Rainer WG. Malignant mesenchymoma in infants. Am J Dis Child128:847–850, 1974
17.
Brar MK, Cubberley DA, Baty BJ, Branch DW. Chest wall hamartoma in a fetus. J Ultrasound Med7:217–220, 1988
18.
Serrano-Egea A, Santos-Briz A, Garcia-Munoz H, Martinez-Tello FJ. Chest wall hamartoma. Report of two cases with secondary aneurysmal bone cysts. Pathol Res Pract197:835–839, 2001
19.
Baretton G, Stehr M, Nerlich A, Lohrs U. Chest wall hamartoma in infancy: A case report with immunohistochemical analysis of various interstitial collagen types. Pediatr Pathol14:3–9, 1994
20.
D'Ercole C, Boubli L, Potier A, Borrione CL, Leclaire M, Blanc B. Fetal chest wall hamartoma: A case report. Fetal Diagn Ther9:261–263, 1994
21.
Dounies R, Chwals WJ, Lally KP, Isaacs H, Jr, Senac MO, Hanson BA, Mahour GH, Sherman NJ. Hamartomas of the chest wall in infants. Ann Thorac Surg57:868–875, 1994
22.
Masuzaki H, Masuzaki M, Ishimaru T, Yamabe T. Chest wall hamartoma diagnosed prenatally using ultrasonography and computed tomography. J Clin Ultrasound24:83–85, 1996
Brand T, Hatch EI, Schaller RT, Stevenson JK, Arensman RM, Schwartz MZ. Surgical management of the infant with mesenchymal hamartoma of the chest wall. J Pediatr Surg21:556–558, 1986
25.
Odell JM, Benjamin DR. Mesenchymal hamartoma of chest wall in infancy: Natural history of two cases. Pediatr Pathol5:135–146, 1986
26.
Gwyther SJ, Hall CM. Mesenchymal hamartoma of the chest wall in infancy. Clin Radiol43:24–25, 1991
27.
Troum S, Dalton ML, Donner RS, Besser AS. Multifocal mesenchymal hamartoma of the chest wall in infancy. J Pediatr Surg31:713–715, 1996
28.
Cameron D, Ong TH, Borzi P. Conservative management of mesenchymal hamartomas of the chest wall. J Pediatr Surg36:1346–1349, 2001
29.
McCarthy EF, Dorfman HD. Vascular and cartilaginous hamartoma of the ribs in infancy with secondary aneurysmal bone cyst formation. Am J Surg Pathol4:247–253, 1980
30.
Balci P, Obuz F, Gore O, Yilmaz E, Demirpolat G, Aktug T, Kovanlikaya I. Aneurysmal bone cyst secondary to infantile cartilaginous hamartoma of rib. Pediatr Radiol27:767–769, 1997
31.
Gore O, Kilicalp A, Basdemir G, Ozer E, Aktug T. Cartilaginous hamartoma of the chest wall with secondary aneurysmal cyst-like areas in an infant: A case report. Turk J Pediatr41:139–142, 1999
32.
Keynan O, Fisher CG, O'Connell JX, Boyd M, Dvorak MF. Mesenchymal hamartoma of the spine. A case report. J Bone Joint Surg Am87:172–176, 2005
33.
McDermott MB, Ponder TB, Dehner LP. Nasal chondromesenchymal hamartoma: An upper respiratory tract analogue of the chest wall mesenchymal hamartoma. Am J Surg Pathol22:425–433, 1998
34.
Norman E, Bergman S, Trupiano J. Nasal chondromesenchymal hamartoma: Report of a case and reivwe of the literature. Pediatr Dev Pathol7:517–520, 2004
