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Abstract

The possible relationship between gastric metaplasia and ulcerative lesions in an anusual case of ulcerative jejunitis not related to celiac disease and with extensive gastric meta-plasia is discussed. Previous studies have described gastric metaplasia in duodenal ulcers on the basis of endoscopic data, and some authors maintain that acid secretion in meta-plastic mucosa could represent a pathogenetic factor of ulcerogenesis, with a self-amplifying mechanism. In the absence of functional evidence, we could provide data, in a case of ulcerative jejunitis, about morphologic signs of acid secretion in gastric metaplastic epithelium using an antibody against HMFG-1, a good marker of acid-secreting fundic cells. Metaplastic areas demonstrated a focal positivity for HMFG-1, and these finding are suggestive of local acid secretion.

Keywords

ulcerative duodenitis HMFG 1 metaplasia acid secretion

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Gastric Metaplasia and Small Bowel Ulcerogenesis in a Case of Ulcerative Jejunitis Not Related to Celiac Disease

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