Sentinel lymph node biopsy has attained “standard of care” status in the management of breast carcinoma. However, the pathological interpretation and clinical consequences of “minimally involved” sentinel lymph nodes remain controversial. Herein, we present some of the complex and challenging pathological problems inherent in this evolving setting. Clearly, at least some of our current concepts regarding “minimally involved” sentinel lymph nodes need reappraisal.
Giuliano AE. Sentinel node biopsy: Standard of care. Breast J9:S1-S6; 2003
2.
Viale G, Maiorano E, Mazzarol G, et al. Histologic detection of and clinical implication of micrometastases in axillary sentinel nodes in patients with breast carcinoma. Cancer92:1378-13842001
3.
Cserni C, Amendoeira I, Apostolikas N, et al. Pathological work-up of sentinel lymph nodes in breast cancer. Review of current data to be considered for the formulation of guidelines. Eur J Cancer39:1654-16572003
4.
Veronesi U, Paganelli, Viale G. Sentinel lymph node biopsy and axillary dissection in breast cancer: Results in a large series. J Natl Cancer Inst91:368-3711999
5.
Smith PAF, Harlow SP, Krag DN, et al. Submission of lymph node tissue for ancillary studies decreases accuracy of conventional breast cancer axillary node staging. Mod Pathol12:781-7851999
6.
Yared MA, Middleton LP, Smith TL. Recommendations for sentinel lymph node processing in breast cancer. Am J Surg Pathol26:138-1412002
7.
Cohen C, Alazraki, Styblo T, et al. Immunohistochemical evaluation of sentinel lymph nodes in breast carcinoma patients. Appl Immunohistochem Mol Morph10:296-3032002
8.
Association of Directors of Anatomic and Surgical Pathology. ADASP recommendations of processing and reporting lymph node specimens submitted for evaluation of metastatic disease. Am J Surg Pathol25:961-9632001
9.
Michael L, Cibull MD, for the College of American Pathologists’ Surgical Pathology Committee. Handling sentinel lymph node biopsy specimen. Arch Pathol Lab Med123:620-6211999
10.
Hoda SA, Chiu A, Resetkova E, Harigopal M, Osborne MP. Pathological examination of sentinel lymph nodes. Potential problems and possible solutions. Microsc Res Tech59:85-912002
11.
Sobin LH, Wittekind CH, eds. UICC TNM Classification of malignant tumors. 6th ed.Springer, New York, pp. 131-142, 2002
12.
Cote RJ, Peterson HF, Chaiwun B, Gelber RD, Goldhirsch A, Castiglione-Gertsch M, Gusterson B, Neville AM. Role of immunohistochemical detection of lymph node metastases in management of breast cancer. International Breast Cancer Study Group. Lancet354:896-9001999
13.
Huvos AG, Hutter RVP, Berg JW. Significance of axillary metastases and micrometastases in mammary cancer. Ann Surg173:44-461971
14.
Resetkova E, Hoda SA, Clarke J, Rosen PP. Benign heterotopic epithelial inclusions in axillary lymph nodes—histological and immunohistochemical patterns. Arch Pathol Lab Med127:e25-e272003
15.
Hoda SA, Resetkova E, Yusuf Y, Cahan A, Rosen PP. Megakaryocytes mimicking metastatic metastatic breast carcinoma. Arch Pathol Lab Med126:618-6202002
16.
Chiu A, Hoda RS, Hoda SA. Pseudometastasis in sentinel lymph node: Multinucleated macrophages mimicking micrometastasis. Breast J7:440-4412001
17.
Cody HS, Borgen PI, Liberman L. The detection and significance of axillary lymph node micrometastases. In Bland KI, Copeland EM (eds): Breast cancer. Elsevier, St.Louis, pp. 1081-1091, 2003
18.
Schwartz GF, Giuliano AE, Veronesi U, and the Consensus Conference Committee. Proceedings of the consensus conference on the role of sentinel lymph node biopsy in carcinoma of the breast, April 19-22, 2001, Philadelphia, PA. Cancer94:2542-25512002
19.
Saphir O, Amronin GD. Obscure axillary lymph node metastasis in carcinoma of the breast. Cancer1:238-2411948
20.
Wilkinson EJ, Hause LL, Hoffman RG, Kuzma JF, Rothwell DJ, Donegan WL, Clowry LJ, Almagro UA, Choi H, Rimm AA. Occult axillary lymph node metastasis in invasive breast carcinoma characteristics of the primary tumor and significance of the metastases. Pathol Annu17(pt 2):67-91, 1982
21.
Ridolfi RL, Rosen PP, Thaler H. Nevus cell aggregates associated with lymph nodes: Estimated frequency and clinical significance. Cancer39:164-1711997
22.
Rosen PP. Rosen’s Breast pathology. Lippincott, Philadelphia, pp. 342-343, 2001
23.
Dowlatshahi K, Fan M, Snider HC, et al. Lymph node micrometastases from breast carcinoma: Reviewing the dilemma. Cancer80:1188-11971997
24.
Weaver DL. Sentinel lymph nodes and breast carcinoma: Which micrometastases are clinically significant? Am J Surg Pathol27:842-8452003
25.
Farshid G, Pardhan M, Kollias J, et al. Computer simulation of lymph node metastases for optimizing the pathologic examination of sentinel lymph nodes in patients with breast carcinoma. Cancer89:2527-25372000