A 52-year-old woman presented with abdominal pain and hematochezia. A colonoscopy showed a polypoid mass in the descending colon. A left hemicolectomy revealed a well-differentiated liposarcoma forming a polypoid intraluminal mass and an ill-defined nodule in the adjacent mesocolon. She remained well 2 years later. A review of the literature revealed only 2 reported cases of colonic liposarcoma, 1 of the myxoid type, and the other of the pleomorphic type. Two other possible cases of well-differentiated liposarcoma of the colon were uncovered from the literature.
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