This article postulates the impact the use of Selective Serotonin Reuptake Inhibitors (SSRIs) may have on relationship satisfaction. Three phases are represented in romantic love: attraction, lust, and attachment. Both the use of SSRIs and each of these stages of love affect the brain's neurochemistry. However , relationship satisfaction may be impaired due to the chemical changes induced from ingestion of the SSRI medication. Neurotransmitters influenced by romantic love—dopamine, oxytocin, and vasopressin—may be hindered from the increase in serotonin, thus decreasing relationship satisfaction in romantic partners. Therefore, couples therapists need to be cognizant of all variables that may be influencing relationships such as medications and cultural and gender differences.