To report four cases of fixed drug eruption induced by hydroxyzine hydrochloride (Otarex, Teva, Israel).
Case Summary
Four children with restlessness who were treated with hydroxyzine hydrochloride developed fixed drug eruption of the penis. Drug discontinuation was followed by complete resolution of the skin eruption. Rechallenge resulted in the same drug rash. Macrophage migration inhibiting factor (MIF) assay with hydroxyzine hydrochloride was positive.
Discussion
The pathogenesis of fixed drug eruption and the role of macrophage MTF assay in diagnosis is discussed.
Conclusions
A fixed drug eruption induced by hydroxyzine hydrochloride is possible, but is a rare phenomenon.
Get full access to this article
View all access options for this article.
References
1.
WallaceJ.H., HymanA.B.. Disorder of external genitalia. Drug eruptions. In: FitzpatrickT.B., EisenA.Z., WolffK., FreedbergI., AustenK.F., eds. Dermatology in general medicine.New York: McGraw-Hill, 1979; 911.
2.
SavinJ.A.. Current causes of fixed drug eruptions. Br J Dermatol1970; 83: 546–9.
3.
HalevyS., GrunwaldM.H., SandbankM., BuimoviceB., JoshuaH., LivniE.. Macrophage migration inhibition factor (MIF) in drug eruption. Arch Dermatol1990; 126: 48–51.
4.
KorkijW., SoltaniK.. Fixed drug eruption. Arch Dermatol1984; 120: 520–2.
5.
ShelleyW.B., SchlappnerO.L.A., HeissH.B.. Demonstration of intercellular immunofluorescences and epidermal hysteresis in bullous fixed drug eruption due to Phenolphthalein. Br J Dermatol1972; 86: 118–25.
6.
DuhraP., PorterD.I.. Paracetamol induced fixed drug eruption with positive immunofluorescence findings. Clin Exp Dermatol1990; 15: 296–7.
7.
DavidJ.R., Al-AskarisS., LawrenceH.S., ThomasI.. Delayed hypersensitivity in vitro. 1: the specificity of inhibitor cell migration by antigens. J Immunol1964; 92: 264–73.
8.
WolfR., LivniE., JoshuaH.. Concurrent cell-mediated immunity and immediate hypersensitivity in animal model. Ann Allergy1984; 52: 300–2.
9.
AmirJ., ShuperA., VarsanoI., LivniE., MimouniM.. Fixed drug eruption of the penis due to co-trimoxazole. Drug Intell Clin Pharm1987; 21: 41–2.
