Changes in Interleukin-6 Concentrations following Epilepsy Surgery: Potential Influence on Carbamazepine Phannacokinetics

Abstract

Get full access to this article

View all access options for this article.

References

Spencer

Packey

. Antiepileptic drug management before and after epilepsy surgery. In: Levy

Mattson

Meldrum

, eds. Antiepileptic drugs. 4th ed. New York: Raven Press, 1995: 189–200.

Cruz-Rodriguez

Graves

Leppik

Wilder

. Carbamazepine toxicity after epilepsy surgery (abstract). Epilepsia 1989: 30: 640.

Gidal

Spencer

Maly

Pitterle

. Evaluation of carbamazepine and carbamazepine epoxide protein binding in patients undergoing epilepsy surgery. Epilepsia 1996; 37: 381–5.

Cloyd

. Pharmacokinetic pitfalls of present antiepileptic medications. Epilepsia 1991; 32 (suppl 5): S53–65.

Dinarello

. Interleukin-1 and the pathogenesis of the acute phase response. N Engl J Med 1984; 311: 1413–8.

Young

Ott

Beard

Dempsey

Tibbs

McClain

. The acute phase response of the brain injured patient. J Neurosurg 1988; 69: 375–80.

Kerr

Thummel

Wurden

Klein

Kroetz

Gonzalez

. Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation. Biochem Pharmacol 1994; 47: 1969–79.

Chen

Florentin

Batt

Ferrari

Giroud

Chauvelot-Moachon

. Effects of interleukin-6 on cytochrome P450-dependent mixed function oxidases in the rat. Biochem Pharmacol 1992; 44: 137–48.

Fukuda

Ishida

Noguchi

Kappas

Sassa

. Interleukin-6 down regulates the expression of transcripts encoding cytochrome P450 IA1, IA2 and IIIA3 in human hepatoma cells. Biochem Biophys Res Commun 1992; 184: 960–5.

10.

Toler

Young

McClain

Shedlofsky

Bandyopadhyay

Blouin

. Head injury and cytochrome P-450 enzymes. Differential effect on mRNA and protein expression in the Fischer-344 rat. Drug Metab Dispos 1993; 21: 1064–9.

11.

Griffeth

Rosen

Rauchman

. Effects of model traumatic injury on hepatic drug metabolism in the rat. VI. Major detoxification/toxification pathways. Drug Metab Dispos 1987; 15: 749–59.

12.

Chen

Vraux

Leneveu

Dreyfus

Stheneur

Florentin

. Acute phase response, interleukin-6, and alteration of cyclosporine pharmacokinetics. Clin Pharmacol Ther 1994; 55: 649–60.

13.

Fukuda

Sassa

. Suppression of cytochrome P450IA1 by interleukin-6 in human HepG2 hepatoma cells. Biochem Pharmacol 1994; 47: 1187–95.

14.

Moochhala

Renton

. Induction and depression of cytochrome P450 dependent mixed function oxidase by a cloned concecsus α-interferon (INF-αCON₁) in the hamster. Biochem Pharmacol 1989; 38: 439–47.