Efficacy of Mesna for Prevention of Hemorrhagic Cystitis After High-Dose Cyclophosphamide Therapy

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References

Schoenike

, Dana

. Ifosfamide and mesna. Clin Pharm 1990;9:179-91.

Atkinson

, Biggs

, Noble

, Ashby

, Concannon

, Dodds

Preparative regimens for marrow transplantation containing busulphan are associated with haemorrhagic cystitis and hepatic veno-occlusive disease but a short duration of leucopenia and little oro-pharyngeal mucositis. Bone Marrow Transplant 1987;2:385-94.

Ost

, Lonnqvist

, Eriksson

, Ljungman

, Ringden

Hemorrhagic cystitis—-a manifestation of graft-versus-host disease?

Bone Marrow Transplant 1987;2:19-25.

Arthur

, Shah

, Baust

, Santos

, Saral

Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplants. N Engl J Med 1986;315:230-4.

DeVries

, Freiha

. Hemorrhagic cystitis: a review. J Urol 1990;143:1-9.

Package insert. Cytoxan (cyclophosphamide). Princeton, NJ: Mead Johnson Oncology Products, November 1992.

Tutschka

, Copelan

, Klein

. Bone marrow transplantation for leukemia following a new busulfan and cyclophosphamide regimen. Blood 1987;70:1382-8.

Atkinson

, Biggs

, Golovsky

, Concannon

, Dodds

, Downs

. Bladder irrigation does not prevent haemorrhagic cystitis in bone marrow transplant recipients. Bone Marrow Transplant 1991;7:351-4.

Hows

, Mehta

, Ward

, Woods

, Perez

, Gordon

. Comparison of mesna with forced diuresis to prevent cyclophosphamide induced haemorrhagic cystitis in marrow transplantation: a prospective randomised study. Br J Cancer 1984;50:753-6.

10.

Shepherd

, Pringle

, Barnett

, Klingermann

, Reece

, Phillips

. Mesna versus hyperhydration for the prevention of cyclophosphamide-induced hemorrhagic cystitis in bone marrow transplantation. J Clin Oncol 1991;9: 2016-20.

11.

Vose

, Reed

, Pippert

, Anderson

, Bierman

, Kessinger

. Mesna compared with continuous bladder irrigation as uroprotection during high-dose chemotherapy and transplantation: a randomized trial. J Clin Oncol 1993;11:1306-10.

12.

Droller

, Saral

, Santos

Prevention of cyclophosphamide-induced hemorrhagic cystitis. Urology 1982;20:256-8.

13.

Package insert. Mesnex (mesna). Princeton, NJ: Mead Johnson Oncology Products, October 1993.

14.

Brock

, Pohl

, Stekar

Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention. I. Eur J Cancer 1981;17:595-607.

15.

Sladek

, Smith

, Blatt

, Low

, Powers

, Borch

. Influence of diuretics on urinary general base catalytic activity and cyclophosphamide-induced bladder toxicity. Cancer Treat Rep 1982;66:1889-900.

16.

Shaw

, Graham

. Mesna—-a short review. Cancer Treat Rev 1987;14:67-86.

17.

Link

, Neef

, Niethammer

, Wilms

Prophylaxis of haemorrhagic cystitis due to cyclophosphamide-conditioning for bone marrow transplantation (letter). Blut 1981;43:329-30.

18.

Blacklock

, Ball

, Knight

, Schey

, Prentice

Experience with mesna in patients receiving allogeneic bone marrow transplants for poor prognostic leukaemia. Cancer Treat Rev 1983;10(suppl A):45-52.

19.

Nicolau

, Hogan

. National survey of use of mesna for the prevention of cyclophosphamide-induced hemorrhagic cystitis in recipients of bone marrow transplants. Mayo Clin Proc 1992;67:611-2.

20.

Champlin

, Horowitz

, Van Bekkum

, Camilla

, Elfenbein

, Gale

. Graft failure following bone marrow transplantation for severe aplastic anemia: risk factors and treatment results. Blood 1989;73:606-13.

21.

Letendre

, Hoagland

, Gertz

. Hemorrhagic cystitis complicating bone marrow transplantation. Mayo Clin Proc 1992;67:128-30.