WaniMCTaylorHLWallMECoggonPMcPhailAT. Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc1971; 93: 2325–7.
2.
RowinskyEKOnettoNCanettaRMArbuckSG. Taxol: The first of the taxanes, an important new class of antitumor agents. Semin Oncol1992; 19: 646–62.
3.
National Cancer Institute clinical brochure: Taxol NSC 125973. Bethesda, MD: Division of Cancer Treatment, National Cancer Institute, September 1983.
4.
GremJLTutschKDSimonKJAlbertiDBWillsonJKTormeyDC. Phase I study of taxol administered as a short iv infusion daily for 5 days. Cancer Treat Rep1987; 71: 1179–84.
5.
LeghaSSTenneyDMKrakoffIR. Phase I study of taxol using a 5-day intermittent schedule. J Clin Oncol1986; 4: 762–6.
6.
KrisMGO'ConnellJPGrallaRJWertheimMSParenteRMSchiffPB. Phase I trial of taxol given as a 3-hour infusion every 21 days. Cancer Treat Rep1986; 70: 605–7.
7.
WiernikPHSchwartzELStraumanJJDutcherJPLiptonRBPaiettaE. Phase I clinical and pharmacokinetic study of taxol. Cancer Res1987; 47: 2486–93.
8.
DonehowerRCRowinskyEKGrochowLBLongneckerSMEttingerDS. Phase I trial of taxol in patients with advanced cancer. Cancer Treat Rep1987; 71: 1171–7.
9.
BrownTHavlinKWeissGCagnolaJKoellerJKuhnJ. A phase I trial of taxol given by a 6-hour intravenous infusion. J Clin Oncol1991; 9: 1261–7.
10.
WiernikPHSchwartzELEinzigAStraumanJJLiptonRBDutcherJP. Phase I trial of taxol given as a 24-hour infusion every 21 days: Responses observed in metastatic melanoma. J Clin Oncol1987; 5: 1232–9.
11.
OhnumaTZimetASCoffeyVA. Phase I study of taxol in a 24-h infusion schedule (abstract 662). Proc Am Assoc Cancer Res1985; 26: 167.
12.
RowinskyEKBurkePJKarpJETuckerRWEttingerDSDonehowerRC. Phase I and pharmacodynamic study of taxol in refractory acute leukemias. Cancer Res1989; 49: 4640–7.
13.
KingstonDGISamaranayakeGIveyCA. The chemistry of taxol, a clinically useful anticancer agent. J Nat Prod1990; 53: 1–12.
14.
National Cancer Institute clinical brochure: taxol IND 22850, NSC 125973. Bethesda, MD: Division of Cancer Treatment, National Cancer Institute; revised, August 1990.
15.
HanauskeA-RDegenDHilsenbeckSGBisseryMCVon HoffDD. Effects of Taxotere and taxol on in vitro colony formation of freshly explanted human tumor cells. Anti-Cancer Drugs1992; 3: 121–4.
16.
WeissRBDonehowerRCWiernikPHOhnumaTGrallaRJTrumpDLHypersensitivity reactions from taxol. J Clin Oncol1990; 8: 1263–8.
17.
SarosyGKohnEStoneDARothenbergMJacobJAdamsDOPhase I study of taxol and granulocyte colony-stimulating factor in patients with refractory ovarian cancer. J Clin Oncol1992; 10: 1165–70.
18.
RowinskyEKGilbertMRMcGuireWPGrochowLBForastiereAAEttingerDJSequences of taxol and cisplatin: A phase I and pharmacologic study. J Clin Oncol1991; 9: 1692–1703.
19.
ForastiereAARowinskyEChaudryVSartoriousJLubejkoBEttingerDPhase I trial of taxol (T) and cisplatin (C) + G-CSF in solid tumors (abstract 289). Proc Am Soc Clin Oncol1992; 11: 117.
20.
HolmesFAWaltersRValeroVThieraultRBooserDBuzdarThe M.D. Anderson experience with taxol in metastatic breast cancer. Second National Cancer Institute Workshop on Taxol and Taxus (abstract). Alexandria, VA, 1992.
21.
FishermanJMcCabeMHilligMGoldspielBCowanKHO'ShaughnesseyJAPhase I study of taxol plus doxorubicin plus granulocyte colony stimulating factor (G-CSF) in patients with metastatic breast cancer. Second National Cancer Institute Workshop on Taxol and Taxus (abstract). Alexandria, VA, 1992.
22.
MarkmanMRowinskyEHakesTReichmanBJonesWLewisJLPhase I trial of intraperitoneal taxol: A Gynecologic Oncology Group Study. J Clin Oncol1992; 10: 1485–91.
23.
RowinskyEKCitardiMNoeDADonehowerRC. Sequence-dependent cytotoxic effects due to combinations of cisplatin and the antimicrotubule agents taxol and vincristine. J Cancer Res Clin Oncol. In press.
24.
LassusMScottDLeyland-JonesB. Allergic reactions (AR) associated with cremophor (C) containing antineoplastics (ANP) (abstract C-1042). Proc Am Soc Clin Oncol1985; 4: 268.
25.
HayesFAAbromowitchMGreenAA. Allergic reactions to teniposide in patients with neuroblastoma and lymphoid malignancies. Cancer Treat Rep1985; 69: 439–41.
26.
HowrieDLPtachcinskiRJGriffithBPHardestyRJRosenthalJTBurckartGJAnaphylactoid reactions associated with parenteral cyclosporine use: Possible role of Cremophor EL. Drug Intell Clin Pharm1985; 19: 425–7.
27.
YahandraAMAdlerKMFisherGABrophyNAHalseyJHardyRIPhase I trial of etoposide with cyclosporine as a modulator of multidrug resistance. J Clin Oncol1992; 10: 1624–34.
HüttelMSOlesenSchou AStoffersenE. Complement-mediated reactions to diazepam with Cremophor as solvent (Stesolid MR). Br J Anaesth1980; 52: 77–9.
30.
GlenJBDaviesGEThomsonDSScarthSCThompsonAV. An animal model for the investigation of adverse responses to I.V. anaesthetic agents and their solvents. Br J Anaesth1979; 51: 819–27.
31.
HackerMKoeferlMHongCBFaganMA. Cremophor® and Emulphor® induced alterations of serum lipids and lipoprotein electrophoretic patterns of dogs. Res Commun Chem Pathol Pharmacol1981; 31: 119–28.
32.
BeckWT. The cell biology of multiple drug resistance. Biochem Pharmacol1987; 36: 2879–87.
33.
ChervinskyDSBrecherMLHoelcleMJ. Cremophor-EL reverses taxol cross resistance in murine C1300 multidrug resistant neuroblastoma cells (abstract 2851). Proc Am Assoc Cancer Res1992; 33: 477.
34.
WoodcockDMLinsenmeyerMEChojnowskiGKrieglerAB. Reversal of multidrug resistance by surfactants. Br J Cancer1992; 66: 62–8.
35.
WoodcockDMJeffersonSLinsenmeyerMECrowtherPJChojnowskiGMWilliamsBReversal of the multidrug resistance phenotype with Cremophor EL, a common vehicle for water-insoluble vitamins and drugs. Cancer Res1990; 50: 4199–203.
DorrRTAlbertsDS. Vinca alkaloid skin toxicity: Antidote and drug disposition studies in the mouse. J Natl Cancer Inst1985; 74: 113–20.
38.
DorrRTAlbertsDS. Skin ulceration potential without therapeutic anticancer activity for epipodophyllotoxin commercial diluents. Invest New Drugs1983; 1: 151–9.
39.
van der ValkPvan KalkenCKKetelaarsHBroxtermanHJSchefferGKuiperCMDistribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues. Ann Oncol1990; 1: 56–64.
40.
LongneckerSMDonehowerRCCatesAEChenTLBrundrattRBGrochowLBHigh-performance liquid chromatographic assay for taxol in human plasma and urine and pharmacokinetics in a phase I trial. Cancer Treat Rep1987; 71: 53–9.
41.
RowinskyEKCazenaveLADonehowerRC. Taxol: A novel investigational antimicrotubule agent. J Natl Cancer Inst1990; 82: 1247–59.
42.
MonsarratBMarielECrosSGaresMGuenardDGueritte-VogeleinFTaxol metabolism: Isolation and identification of three major metabolites of taxol in rat bile. Drug Metab Dispos1990; 18: 895–901.
43.
MonsarratBWrightMDuboisJTaxol metabolism in rat and human bile (abstract 258). Ann Oncol1992; 3 (suppl 1):123.
44.
RizzoJRileyCVon HoffDKuhnJPhillipsJBrownT. Analysis of anticancer drugs in biological fluids: Determination of taxol with application to clinical pharmacokinetics. J Pharm Biomed Anal1990; 8: 159–64.
45.
RowinskyEK. The pharmacology of taxol. Second National Cancer Institute Workshop on Taxol and Taxus (abstract). Alexandria, VA, 1992.
46.
MartoniAZamagniCGhekaAPannutiF. Antihistamines in the treatment of taxol-induced paroxystic pain syndrome. J Natl Cancer Inst1993; 85: 676.
47.
McGuireWPRowinskyEKRosensheinNBGrumbineFCEttingerDSArmstrongDKTaxol: A unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann Intern Med1989; 111: 273–9.
48.
ThigpenTBlessingJBallHHummelSBarretR. Phase II trial of taxol as second-line therapy for ovarian carcinoma: A Gynecologic Oncology Group study (abstract 604). Proc Am Soc Clin Oncol1990; 9: 156.
49.
EinzigAIWiernikPHSasloffJRunowiczCDGoldbergGL. Phase II study and long-term follow-up of patients treated with taxol for advanced ovarian adenocarcinoma. J Clin Oncol1992; 10: 1748–53.
50.
SarosyGKohnELinkCDavisPOgnieneFGoldspielBTaxol dose intensification (D.I.) in patients with recurrent ovarian cancer (abstract 716). Proc Am Soc Clin Oncol1992; 11: 226.
51.
HolmesFAWaltersRSTheriaultRLFurmanADNewtonLKRaberMNPhase II trial of taxol, an active drug in the treatment of metastatic breast cancer. J Natl Cancer Inst1991; 83: 1797–805.
52.
SeidmanAReichmanBCrownJBeggCHeelanRHakesT. Activity of taxol with recombinant granulocyte colony stimulating factor (GCSF) as first chemotherapy (C) of patients (pts) with metastatic breast cancer (abstract 64). Proc Am Soc Clin Oncol1992; 11: 59.
53.
NortonLSeidmanAReichmanBCrownJAHeelanRHakesTTaxol plus recombinant human granulocyte colony stimulating factor as initial chemotherapy for metastatic breast cancer. Second National Cancer Institute Workshop on Taxol and Taxus (abstract). Alexandria, VA, September 22–23, 1992.
54.
WilsonWHKangYKBryantGBergSStark-VancesVBatesSPhase I/II study of 96 hour infusional taxol in refractory lymphomas and breast cancer. Second National Cancer Institute Workshop on Taxol and Taxus (abstract). Alexandria, VA, 1992.
55.
MurphyWKFossellaFVWinnRJShionDMHynesHGrossHMPhase II study of taxol in patients with untreated advanced non-small-cell lung cancer. J Natl Cancer Inst1993; 85: 384–8.
56.
ChangAYKimKGlickJAndersonTKarpDJohnsonDPhase II study of taxol merbarone, and piroxantrone in stage IV non-small-cell lung cancer: The Eastern Cooperative Oncology Group results. J Natl Cancer Inst1993; 85: 388–94.
57.
EttingerDSFinkelsteinDMSarmaRJohnsonDH. Phase II study of taxol in patients (PTS) with extensive-stage small cell lung cancer (SCLC): An Eastern Cooperative Oncology Group study (abstract 1094). Proc Am Soc Clin Oncol1993; 12: 329.
58.
ForastiereAANeubergDTaylorSGIVPhase II evaluation of taxol in advanced head and neck cancer. J Natl Cancer Inst In press.
59.
LeghaSSRingSPapadopoulosNRaberMBenjaminRS. A phase II trial of taxol in metastatic melanoma. Cancer1990; 65: 2478–81.
60.
EinzigAIHochsterHWiernikPHTrumpDLDutcherJPGarowskiEA phase II study of taxol in patients with malignant melanoma. Invest New Drugs1991; 9: 59–64.
61.
WiernikPHEinzigAI. Taxol in malignant melanoma. Second National Cancer Institute Workshop on Taxol and Taxus (abstract). Alexandria, VA, September 22–23, 1992.
62.
EinzigAIGorowskiESasloffJWiernikPH. Phase II trial of taxol in patients with metastatic renal cell carcinoma. Cancer Invest1991; 9: 133–6.
63.
RothBYeapBWildingGKasimisBMcLeodDLoehrerXTaxol (NSC 125973) in advanced, hormone-refractory prostate cancer: An ECOG phase II trial (abstract 598). Proc Am Soc Clin Oncol1992; 11: 196.
64.
RowinskyEKDonehowerRCJonesRJTuckerRW. Microtubule changes and cytotoxicity in leukemic cell lines treated with taxol. Cancer Res1988; 48: 4093–100.
65.
LeBlancGASundsethSSWeberGFWaxmanDJ. Platinum anticancer drugs modulate P-450 mRNA levels and differentially alter hepatic drug and steroid hormone metabolism in male and female rats. Cancer Res1992; 52: 540–7.
66.
RowinskyEKChoudhryVForastierraAASarterusSEEttingerDSGrochowLBA Phase I and pharmacologic study of taxol and cisplatin with granulocyte colony-stimulating factor: Neuromuscular toxicity is dose-limiting. J Clin Oncol1993; 11: 2010–20.
67.
McGuireWPHoskinsWJBradyMFKuceraPRLookKYPartridgeEEA Phase III trial comparing cisplatin/cytoxan and cis-platintaxol in adv anced ovarian cancer (abstract 808). Proc Am Soc Clin Oncol1993; 12: 255.
68.
SwenertonKEisenhauerEten Bokkel HuininkWMilesJMangioneCvan den BurgMTaxol in relapsed ovarian cancer: High vs low dose and short vs long infusion: A European-Canadian study coordinated by the NCI Canada Clinical Trials Group (abstract 810). Am Soc Clin Oncol1993; 12: 256.
69.
TishlerRBSchiffPBGeardCRHallEJ. Taxol: A novel radiation sensitizer. Int J Radiat Oncol Biol Phys1992; 22: 613–7.
70.
SlichenmyerWMcGuireWDonehowerRBowlingKChenT-LRowinskiEPharmacologic and toxic effects of various histamine-2 (H2A) antagonists in taxol premedication regimens (abstract 440). Proc Am Soc Clin Oncol1993; 12: 160.
71.
Package insert. Taxol (paclitaxel) for injection concentrate. Princeton, NJ: Bristol-Myers Squibb, December 1992.
72.
AdamsJDFloraKPGoldspielBRWilsonJWArbuckSFinleyR. Taxol (paclitaxel): A history of pharmaceutical development and current pharmaceutical concerns. J Natl Cancer Inst Monogr In press.
73.
MoorhatchPChiouWL. Interactions between drugs and plastic intravenous fluid bags. Part II: Leaching of chemicals from bags containing various solvent media. Am J Hosp Pharm1974; 31: 149–52.
74.
VenkataramananRBurckartGJPtachcinskiRJBlahaRLogueLWBahnsonALeaching of diethylhexyl phthalate from polyvinyl chloride bags into intravenous cyclosporine solution. Am J Hosp Pharm1986; 43: 2800–2.
75.
WaughWNTrisselLAStellaVJ. Stability, compatibility, and plasticizer extraction of taxol (NSC-125973) injection diluted in infusion solutions and stored in various containers. Am J Hosp Pharm1991; 48: 1520–4.
76.
Van DoorenAA. PVC as a pharmaceutical packaging material: A literature survey with special emphasis on plasticized PVC bags. Pharm Weekbl Sci1991; 13: 109–18.
77.
GanningAEBrunkUDallnerG. Phthalate esters and their effect on the liver. Hepatology1984; 4: 541–7.
78.
GarveyLKSwenbergJAHammTEPoppA. Di(2-ethylhexyl)phthalate: Lack of initiating activity in the liver of female F-344 rats. Carcinogenesis1987; 8: 285–90.
79.
KamrinMAMayorGH. Diethyl phthalate: A perspective. J Clin Pharmacol1991; 31: 484–9.
80.
SmithAThrussellIRJohnsonGW. The prevention of plasticizer migration into nutritional emulsion mixtures by use of a novel container. Clin Nutr1989; 8: 173–7.
81.
FlaminioLMDe AngelisLFerazzaMMarinovichMGalliGGalliCL. Leachability of a new plasticizer tri-(2-ethylhexyl)-trimellitate from haemodialysis tubing. Int J Artif Organs1988; 11: 435–41.
82.
RathinamKSrivastavaSPSethPK. Hepatic studies of intraperitoneally administered tris(2-ethyl hexyl)trimellitate (TOTM) and di(2-ethyl hexyl)phthalate in rats. J Appl Toxicol1990; 10: 39–41.
Data on file. Bristol-Myers Squibb Company, Princeton, NJ.
85.
TrisselLABreadyBB. Turbidimetric assessment of the compatibility of taxol with selected other drugs during simulated Y-site injection. Am J Hosp Pharm1992; 49: 1716–9.
86.
TrisselLAMartinezJF. Turbidimetric assessment of the compatibility of taxol with 42 other drugs during simulated Y-site injection. Am J Hosp Pharm1993; 50: 300–4.
87.
FogelJBokserAGoldspielBRChatterjiDCGallelliJF. Compatibility of admixtures of doxorubicin hydrochloride and taxol in 5% dextrose injection (abstract). Presented at the Eastern States Resident's Conference, Baltimore, MD: April 10, 1992.
88.
RowinskyEKMcGuireWPDonehowerRC. The current status of taxol. In: HoskinsWJPerezCAYoungRC, eds. Principles and practice of gynecologic oncology updates. Philadelphia: JB Lippincott; 1993: 1–16.
89.
RowinskyEKEisenhauerEAChaudhryVArbuckSG. Clinical toxicities encountered with taxol. Semin Oncol1993; 20 (suppl 2). In press.
90.
FishermanJMcCabeMHilligMGoldspielBCowanKHO'ShaughnessyJO. Phase I study of taxol and doxorubicin (DOX) with G-CSF in previously untreated metastatic breast cancer (MBC) (abstract 54). Proc Am Soc Clin Oncol1992; 11: 57.
91.
LiptonRBApfelSCDutcherJPRosenbergRKaplanJBergerATaxol produces a predominantly sensory neuropathy. Neurology1989; 39: 368–73.
92.
RowinskyEKBurkePJKaprJETuckerRWEttingerDSDonehowerRC. Phase I and pharmacodynamic study of taxol in refractory acute leukemia. Cancer Res1989; 49: 4640–7.
93.
ApfelSCLiptonRBArrezzoJCKesslerJA. Nerve growth factor prevents toxic neuropathy in mice. Ann Neurol1991; 29: 87–90.
94.
PetersonERCrainSM. Nerve growth factor attenuates neurotoxic effects of taxol on spinal cord-ganglion explants from fetal mice. Science1982; 217: 377–9.
95.
BrownTHavlinKWeissGCagnolaJKoellerJKuhnJA phase I trial of taxol given by a 6-hour intravenous infusion. J Clin Oncol1991; 9: 1261–7.
96.
RowinskyEKMcGuireWPGuarnieriTFishermanJSChristianMCDonehowerRC. Cardiac disturbances during the administration of taxol. J Clin Oncol1991; 9: 1704–12.
97.
PeereboomDDonehowerRCEisenhauerEAMcGuireWPOnettoNHubbardJLSuccessful re-treatment with taxol after major hypersensitivity reactions. J Clin Oncol (in press).
98.
HolmesFAFryeDValeroVWaltersRSTheriaultRLBooserDPhase I study of paclitaxel (T) and doxorubicin (D) with G-CSF in patients (PT) without prior chemotherapy (CT) for metastatic breast cancer (MBC) (abstract 66). Proc Am Soc Clin Oncol1992; 11: 60.
99.
AjaniJADoddLGDaughertyKWarkentinDIlsonDH. Taxol-induced soft tissue injury secondary to extravasation: Characterization by histopathology and clinical course. J Natl Cancer Insti1994; 86: 51–3.