To describe the efficacy of ondansetron for the treatment of poisoning-associated vomiting in two patients following drug intoxication.
PATIENTS:
Two self-poisoned adolescent patients.
INTERVENTION:
Intravenous ondansetron.
RESULTS:
Resolution of nausea and vomiting in both patients.
CONCLUSIONS:
Ondansetron appears to be a very effective antiemetic drug for use in selected intoxicated patients.
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References
1.
RogersGCJrMatyunasNJ. Gastrointestinal decontamination for acute poisoning. Pediatr Clin North Am1986; 33: 261–97.
2.
GivensTHollowayMWasonS. Pulmonary aspiration of activated charcoal: A complication of its misuse in overdose management. Pediatr Emerg Care1992; 8: 137–40.
3.
KuligK. Initial management of ingestions of toxic substances. N Engl J Med1992; 326: 1677–81.
4.
OlsonKRPentelPRKelleyMT. Physical assessment and differential diagnosis of the poisoned patient. Med Toxicol1987; 2: 52–81.
5.
ColdJAWellsBGFroemmingJH. Seizure activity associated with antipsychotic therapy. DICP Ann Pharmacother1990; 24: 601–6.
6.
BurnettePKPerkinsJ. Parenteral ondansetron for the treatment of chemotherapy and radiation-induced nausea and vomiting. Pharmacother1992; 12: 120–31.
GravesT. Ondansetron: A new entity in emesis control. DICP Ann Pharmacother1990; 24 (suppl):S51–4.
9.
AndrewsPLRDavisCJBinghamSDavidsonHIMHawthornJMaskellL. The abdominal visceral innervation and the emetic reflex: Pathways, pharmacology, and plasticity. Can J Physiol Pharmacol1990; 68: 325–45.
10.
LeeserJLipH. Prevention of postoperative nausea and vomiting using ondansetron, a new selective, 5-HT3 receptor antagonist. Anesth Analg1991; 72: 751–3.
11.
LarijaniGEGratzIAfsharMMinassianS. Treatment of postoperative nausea and vomiting with ondansetron: A randomized, double-blind comparison with placebo. Anesth Analg1991; 73: 246–9.
12.
KennyGNCOatesJDLLeeserJRowbothamDJLipHRustMEfficacy of orally administered ondansetron in the prevention of postoperative nausea and vomiting: A dose ranging study. Br J Anaesth1992; 68: 466–70.
13.
TobiasJDGregoryDFDeshpandeJK. Ondansetron to prevent emesis following N-acetylcysteine for acetaminophen intoxication. Pediatr Emerg Care1992; 8: 345–6.
14.
BrownSGAPrenticeDA. Ondansetron in the treatment of theophylline overdose. Med J Aust1992; 156: 512.
15.
SageTAJonesWNClarkRF. Ondansetron in the treatment of intractable nausea associated with theophylline toxicity. Ann Pharmacother1993; 27: 584–5.
16.
RumackBHPetersonRG. Acetaminophen overdose: Incidence, diagnosis, and management in 416 patients. Pediatrics1978; 62 (suppl):898–903.
