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Abstract

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OBJECTIVE:

To report three cases of life-threatening hypersensitivity reactions to the oral administration of ciprofloxacin.

CASE SUMMARY:

Life-threatening hypersensitivity reactions to oral ciprofloxacin, characterized by diffuse, erythematous, nonpruritic, blanching rash, with fever and hypotension, occurred in two HIV-infected patients. One of these reactions was considered anaphylactoid. A similar hypersensitivity reaction was documented in a non—HIV-infected patient.

DISCUSSION:

Premarketing clinical trials described no reports of life-threatening anaphylactoid hypersensitivity reactions to ciprofloxacin. However, postmarketing surveillance studies have documented their occurrence. Seven cases of anaphylactoid reaction to ciprofloxacin have now been documented in HIV-infected patients.

CONCLUSIONS:

As with trimethoprim/sulfamethoxazole, HIV-infected people treated with ciprofloxacin may be at special risk for hypersensitivity reactions.

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Hypersensitivity and Anaphylactoid Reactions to Ciprofloxacin