Treatment of Urokinase-Related Anaphylactoid Reaction with Intravenous Famotidine

Abstract

OBJECTIVE:

We describe our experience with an anaphylactoid reaction to urokinase and the treatment used. We also discuss the use of histamine H₁- and H₂-blockers in combination for the treatment of allergic anaphylactoid reactions.

DESIGN:

Case report.

SETTING:

Hospital.

PARTICIPANTS:

Observation of a patient who had a pulmonary embolism.

INTERVENTION:

During the use of urokinase, in treatment of a pulmonary embolism, the patient developed an anaphylactoid reaction that did not respond to diphenhydramine or hydrocortisone. Famotidine was administered.

RESULTS:

Abatement of urticaria and normalization of vital signs were obtained soon after famotidine was given. Completion of thrombolysis took place.

CONCLUSIONS:

Further investigation of the use of H₁- and H₂-blocking agents in the presence of anaphylactoid reactions to thrombolytic agents should be performed. Consideration of intravenous famotidine for the treatment of anaphylactoid-type reactions to urokinase is suggested.

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