Adverse Drug Effects: Part II

Smith WCS . Are hypersensitivity reactions to dapsone becoming more frequent. Leprosy Rev 1988; 59: 53–8.

Weber WW Hein DW . N-acetylation pharmacogenetics. Pharmacol Rev 1985; 37: 25–79.

Grossman SJ Jollow DJ . Role of dapsone hydroxylamine in dapsone-induced haemolytic anaemia. J Pharmacol Exp Ther 1988; 244: 118–25.

Uetrecht JP Zahid N Shear NH Biggar WD . Metabolism of dapsone to a hydroxylamine by human neutrophils and mononuclear cells. J Pharmacol Exp Ther 1988; 245: 274–9.

Coleman MD Breckenridge AM Park BK . Bioactivation of dapsone to cytotoxic metabolites by human hepatic microsomal enzymes. Br J Clin Pharmacol 1989; 28: 389–95.

Ganer A Knobel B Fryd CM Rachmilewitz EA . Dapsone induced methaemoglobinaemia and haemolysis in the presence of familial haemoglobin reductase deficiency. Israel J Med Sci 1981; 17: 703–4.

Coleman MD Winn MJ Breckenridge AM Park BK . Inhibition of dapsone induced methaemoglobinaemia in the rat. Biochem Pharmacol 1990; 39: 802–5.

Coleman MD Scott AK Breckenridge AM Park BK . The use of cimetidine as a selective inhibitor of dapsone N-hydroxylation in man. Br J Clin Pharmacol 1990; 30: 761–7.

Tingle MD Coleman MD Park BK . The effect of preincubation with cimetidine on the N-hydroxylation of dapsone by human liver microsomes. Br J Clin Pharmacol 1991; 32: 120–3.

McMillan DC Bradshaw TP Hison JA Jollow DJ . Role of metabolites in propanil-induced hemolytic anemia. Toxicol Appl Pharmacol 1991; 110: 70–8.

Kimbrough RD . Human health effects of selected pesticides, chloroaniline derivatives. J Environ Health 1980; B15: 977–92.

Mianserin 10 years on. Drug Ther Bull 1988; 26: 17–8.

Kitteringham NR Lambert C Maggs JL Colbert J Park BK . A comparative study of the formation of chemically reactive drug metabolites by human liver microsomes. Br J Clin Pharmacol 1988; 26: 13–21.

Riley RJ Maggs JL Lambert C Kitteringham NR Park BK . An in vitro study of the microsomal metabolism and cellular toxicity of phenytoin, sorbinil, and mianserin. Br J Clin Pharmacol 1988; 26: 577–88.

Riley RJ Lambert C Kitteringham NR Park BK . A stereochemical investigation of the cytotoxicity of mianserin metabolites in vitro. Br J Clin Pharmacol 1989; 27: 823–30.

Kinoshita JH Nishimura C . The involvement of aldose reductase in diabetic complications. Diabetes/Metab Rev 1988; 4: 323–37.

Jaspan J . Pharmacological inhibition of aldose reductase in human diabetic neuropathy. Drugs 1986; 33 (suppl 2):23–9.

Poole-Wilson PA . The future role of inotropic drugs. Drugs 1986; 32 (suppl 5):27–32.

Chamberlain DA . Digitalis: Where are we now? Br Heart J 1985; 54: 227–33.

McHaiffie D Purcell H Mitchell-Heggs P Guz A . The clinical value of digoxin in patients with heart failure and sinus rhythm. Quart J Med 1978; 47: 401–19.

Arnold SB Byrd RC Meister W Melmon K Cheitlin MD Bristow JD . Long-term digitalis therapy improves left ventricular function in heart failure. N Engl J Med 1980; 303: 1443–8.

Ware JA Snow E Luchi JM Luchi RJ . Effect of digoxin on ejection fraction in elderly patients with congestive heart failure. J Am Geriatr Soc 1984; 32: 631–5.

Poole-Wilson PA . The role of digitalis in the future. Br J Clin Pharmacol 1984; 18: 151S–6S.

Smith TW . Digitalis: Mechanisms of action and clinical use. N Engl J Med 1988; 318: 358–65.

Moss AJ Davis HT Conard DL DeCamilla JJ Oderoff CL . Digitalis-associated cardiac mortality after myocardial infarction. Circulation 1987; 64: 1150–6.

Bigger JT Jr Fleiss JL Rolnitzky LM Merab JP Ferrick KJ . Effect of digitalis treatment on survival after acute myocardial infarction. Am J Cardiol 1985; 55: 623–30.

Yusuf S Wittes J Bailey K Furberg C . Digitalis—a new controversy regarding an old drug: The pitfalls of inappropriate methods. Circulation 1986; 73: 14–8.

Fleiss JL Bigger JT Jr Rolnitzky LM . Is catch-22 alive and well and living at NHLBI: Reactions to digitalis—a new controversy involving an old drug. Circulation 1986; 73: 19–20.

The MILIS Study Group. National Heart, Lung, and Blood Institute Multicenter Investigation of the Limitation of Infarct Size (MILIS): Design and methods of the clinical trial: An investigation of beta-blockade and hyaluronidase for treatment of acute myocardial infarction. In: Muller JE ed. American Heart Association monograph no. 100. Dallas: American Heart Association, 1984: 1–134.

Muller JE Turi ZG Stone PH Rude RE Raabe DS Jaffe AS . Digoxin therapy and mortality after myocardial infarction. Experience in the MILIS study. N Engl J Med 1986; 314: 265–7.

Marcus FI . The use of digitalis for the treatment of congestive heart failure: A tale of its decline and resurrection. Cardiovasc Drug Ther 1989; 3: 473–6.

Digoxin: New answers; new questions. Lancet 1989; 2: 79–80.

The Captopril-Digoxin Multicenter Research Group. Comparative effects of therapy with captopril and digoxin in patients with mild to moderate heart failure. JAMA 1988; 259: 539–44.

The German and Austrian Xamoterol Study Group. Double-blind placebo-controlled comparison of digoxin and xamoterol in chronic heart failure. Lancet 1988; 1: 489–93.

DiBianco R Shabetai R Kostuk W Moran J Schlant RC Wright RA . A comparison of oral milrinone, digoxin, and their combination in the treatment of patients with chronic heart failure. N Engl J Med 1989; 320: 677–83.

CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure: Results of the Cooperative North Scandinavian Enalapril Survival Study. N Engl J Med 1987; 316: 1429–35.

Tommaso CL . Non-glycoside, non-catecholamine inotropic agents in the treatment of congestive heart failure. Am J Med 1986; 80 (suppl 2B):36–40.

Hilleman DE Forbes WP . Role of milrinone in the management of congestive failure. Drug Intell Clin Pharm 1989; 23: 357–62.

Cohn JN . Inotropic therapy for heart failure: Paradise postponed. N Engl J Med 1989; 320: 729–31.

Packer M Carver JR Rodeheffer FJ Ivanhoe RJ DiBianco R Zeldis SM . Effect of milrinone on mortality in severe chronic heart failure. N Engl J Med 1991; 325: 1468–75.

Enoximone. Lancet 1988; 1: 1085–6.

Uretsky BF Jessup M Konstam MA Dee GW Leier CV Benotti J . Multicenter trial of oral enoximone in patients with moderate to moderately severe congestive heart failure: Lack of benefit compared with placebo. Circulation 1990; 82: 774–80.

Swan HJC . Enoximone in chronic heart failure. Circulation 1990; 82: 1049–50.

Curfman GD . Inotropic therapy for heart failure—an unfulfilled promise. N Engl J Med 1991; 325: 1509–10.