We report a case of hypervagotonia manifested by idioventricular rhythm in a healthy, athletic man who participated in a Phase I study of an investigational calcium-channel blocker. Upon breaking the study's double-blind study code, it was discovered that the subject had received placebo. We discuss this unusual finding and the implications of including athletic subjects in safety/tolerance studies.
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References
1.
DennisonAD. Athletics and the heart. J Indiana Med Assoc1964; 57: 850–2.
2.
HammerWM. Physiological and performance changes during periods of football training and re-training. J Sports Med1965; 5: 72–5.
3.
Hanne-PaparoNWendkosMHBrunnerD. T wave abnormalities in the electrocardiograms of top-ranking athletes without demonstrable organic heart disease. Am Heart J1971; 81: 743–7.
4.
StrasbergBAmat-Y-LeonFDhingraRCNatural history of chronic second-degree antioventricular nodal block. Circulation1981; 63: 1043–9.
