A fatal case of attempting to procure abortion by the ingestion of the crude extract of cantharides from over 200 dried Mylabris phalerata is presented. The quantification of catharidin in blood, urine and liver by gas chromatography using trichloroacetic acid in the extraction process and butobarbitone as the internal standard is described. Ante- and post-mortem blood levels were found to be 0.27 and 0.11 μg/ml respectively. To conclude, the lack of legislative control in Hong Kong over Chinese herbal medicines is highlighted.
Get full access to this article
View all access options for this article.
References
1.
AveryJ. S. (1908) Lancet, 2, 800–1.
2.
ChristisonR. (1936) Treatise of Poisons, 3rd ed., Edinburgh, p. 558–65.
3.
DreisbachR. H. (1974) Handbook of Poisoning: Diagnosis and Treatment, 8th ed., Lange Medical Publications, California, p. 370.
4.
KayeS. (1970) Handbook of Emergency Toxicology, 3rd ed., Thomas, Illinois, p. 185.
5.
LynchJ. P. (1941) Va. Med. Mon., 68, 513–15.
6.
MariF.BertolE.VolpatoI.TostiM.OrzalesiG. (1979) The Detection of Cantharidin in Biological Specimens. J. Anal. Toxicol., 3, 264–5.
7.
Martindale (1982) The Extra Pharmacopoeia, 28th ed. Ed: ReynoldsJ. E. F., The Pharmaceutical Press, London, p. 1689.
8.
MoffatA. C. (ed:) (1986) Clarkes' Isolation and Identification of Drugs in Pharmaceuticals, Body Fluid and Post-Mortem Material, 2nd ed., The Pharmaceutical Press, London, p. 425–426.
9.
PolsonC. J.TattersallR. N. (1959) Clinical Toxicology. English University Press, London, p. 510–19.
10.
SteynJ.M.HundtH. K. L. (1988) Gas Chromatographic-Mass Spectrometric Method for the quantification of Cantharidin in Human Serum. J. Chromatogr., 432, 177–84.