Histamine H2 antagonists, which reduce gastric acid secretion, are often used in the intensive care setting for the prophylaxis of stress ulcers. This double-blind, placebo-controlled study evaluated hemodynamic parameters in 11 stable, critically ill patients receiving famotidine. Repeated-measures ANOVA demonstrated that famotidine had no significant effect on baseline hemodynamic measurements and that there was no significant difference in hemodynamic values following the famotidine infusion as compared with NaCl 0.9% placebo (p>0.05).
Get full access to this article
View all access options for this article.
References
1.
IbertiTJPaluchTAHelmerL, The hemodynamic effects of intravenous cimetidine in intensive care unit patients: A double blinded prospective study. Anesthesiology1986; 64: 87–9.
2.
MahonWAKoltonM. Hypotension after intravenous cimetidine (letter). Lancet1978; 1: 828.
3.
HowardJMChremosANColleenMS, Famotidine, a new, potent, long-acting histamine H2 receptor antagonist: Comparison with cimetidine and ranitidine in the treatment of Zollinger-Ellison syndrome. Gastroenterology1985; 88: 1026–33.
4.
PendletonRGTorchianaMLChungC, Studies on MK-208 (YM-11170), a new slowly dissociable H2-receptor antagonist. Arch Int Pharmacodyn Ther1983; 266: 4–16.
5.
TakagiTTakedaMMaenoH. Effect of a new potent H2-blocker, 3-[[[2-[(diaminomethylene)amino]-4-thiazolyl] methyl]thio]-N2-sulfamoylpropionamid (YM-11170), on gastric secretion induced by histamine and food in conscious dogs. Arch Int Pharmacodyn Ther1982; 256: 49–58.
6.
LocniskarAGreenblattDJHarmatzJSZinnyMAShaderRI. Interaction of diazepam with famotidine and cimetidine, two H2-receptor antagonists. J Clin Pharmacol1986; 26: 299–303.
7.
ImaiYInadaMTamuraSKawataSMinamiYTarviS. Comparative effects of famotidine and cimetidine on 7-ethoxy-coumarin 0-deethylase activity in human livers. Br J Clin Pharmacol1986; 22: 495–6.
8.
RedingPDevroedeCBarbierP. Bradycardia after cimetidine (letter). Lancet1977; 2: 1227.
9.
JensenRTCollenMJPandolSJ, Cimetidine-induced impotence and breast changes in patients with gastric hypersecretory states. N Engl J Med1983; 308: 883–7.
10.
KlotzUArvelaPRosenkranzB. Famotidine, a new H2 receptor antagonist, does not affect hepatic elimination of diazepam or tubular secretion of procainamide. Eur J Clin Pharmacol1985; 28: 671–5.
11.
DonovanMAHeagertyAMPatelLCastledenMPohlJE. Cimetidine and bioavailability of propranolol (letter). Lancet1981; 1: 164.
12.
BreuerHMeschigRBreuerJGoehlichGArnoldG. Hemodynamic studies on cimetidine and ranitidine in anesthetized dogs. Res Exp Med1984; 184: 265–8.
13.
GoelzerSLFarin-RushCCoursinDB. Ranitidine produces minimal hemodynamic depression in stable intensive care unit patients: A double-blind, prospective study. Crit Care Med1988; 16: 8–10.
14.
HeiselmanDEBoykinKMalikM. Hemodynamic status during ranitidine infusion (abstract). Clin Res1989; 37: 104A
15.
ChowJSWangRYWongPHChenWWLaiCL. Intravenous ranitidine has no hemodynamic effects in subjects with normal lung function and patients with chronic obstructive airway disease. Aust N Z J Med1983; 13: 261–3.
16.
KiowskiWFreiA. Bolus injection of cimetidine and hypotension in patients in the intensive care unit. Arch Intern Med1987; 147: 153–6.
17.
SmithCLBardgettDMHunterJM. Haemodynamic effects of the iv administration of cimetidine or ranitidine in the critically ill patient. Br J Anaesth1987; 59: 1397–402.
18.
OwenDAHarveyCABoyceMJ. Effect of histamine on the circulation system. Klin Wochenschr1982; 60: 9972–7.
