The effect of treatment with astemizole for three weeks on weight was assessed in 44 patients with seasonal allergic rhinitis who participated in a randomized, double-blind, placebo-controlled clinical trial. Astemizole 10-mg tablets and identical placebo tablets were used. Compared with baseline, weight increased significantly in astemizole-treated patients (1.07 ± 1.39 kg; p = 0.0004); however, the mean change in weight in astemizole-treated patients was not statistically significantly different than that seen in placebo-treated patients (0.85 ± 1.68 kg). No relationship was found between changes in weight and age, sex, initial weight, percentage of obesity, and plasma astemizole concentrations.
Get full access to this article
View all access options for this article.
References
1.
WihlJAPetersenBNPetersenLNGundersenGBressonKMygindN. Effect of the nonsedative H1-receptor antagonist astemizole in perennial allergic and nonallergic rhinitis. J Allergy Clin Immunol1985; 75: 720–7.
2.
SooknundunMKackerSKSundaramKR. Treatment of allergic rhinitis with a new long-acting H1-receptor antagonist: Astemizole. Ann Allergy1987; 58: 78–81.
3.
HowarthPHHolgateST. Comparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever. Thorax1984; 39: 668–72.
4.
KnightA. Astemizole — A new, non-sedating antihistamine for hay fever. J Otolaryngol1985; 14: 85–8.
5.
TristramSJHarcupJWPatelKR. A comparison of oral astemizole with topical sodium cromoglycate in the treatment of hay fever. Curr Med Res Opin1986; 10: 159–65.
6.
HowarthPHEmanuelMBHolgateST. Astemizole, a potent histamine H1-receptor antagonist: Effect in allergic rhinoconjunctivitis, on antigen and histamine induced skin weal responses and relationships to serum levels. Br J Clin Pharmacol1984; 18: 1–8.
7.
WilsonJDHillasJL. Astemizole: A new long-acting antihistamine in the treatment of seasonal allergic rhinitis. Clin Allergy1983; 13: 131–40.
8.
SalomonssonPGottbergLHeilbornJNorrlindKPegelowKO. Efficacy of an oral antihistamine, astemizole, as compared to a nasal steroid spray in hay fever. Allergy1988; 43: 214–8.
9.
DukesMNG, ed. Meyler's side effects of drugs. 11th ed. Amsterdam: Elsevier, 1988: 27–70.
10.
StokesGSWeberMA. Prazosin: Preliminary report and comparative studies with other antihypertensive agents. Br Med J1974; 2: 298–300.
11.
FalaseALSalakoLAAminuLM. Lack of effect of low doses of prazosin in hypertensive Nigerians. Curr Ther Res1975; 19: 603–11.
12.
SchooleyRTWagleyPFLietmanPS. Edema associated with ibuprofen therapy. JAMA1977; 237: 1716–7.
13.
BrogdenRNHeelRCPakesGESpeightTMAveryGS. Glipizide: A review of its pharmacological properties and therapeutic use. Drugs1979; 18: 329–53.
14.
FowlerLK. Glipizide in the treatment of maturity-onset diabetes: A multi-center study. Curr Med Res Opin1978; 5: 418–23.
15.
LachinJM. Introduction to sample size determination and power analysis for clinical trials. Controlled Clin Trials1981; 2: 93–113.
16.
KrstenanskyPMCluxtonRJJr. Astemizole: A long-acting, non-sedating antihistamine. Drug Intell Clin Pharm1987; 21: 947–53.
17.
RichardsDMBrogdenRNHeelRCAstemizole: A review of its pharmacodynamic properties and therapeutic efficacy. Drugs1984; 28: 38–61.
