Hypertrichosis is a well-recognized adverse effect of therapy with either cyclosporine or minoxidil. We present a case of extreme hypertrichosis in an eight-year-old male liver transplant recipient who received concurrent cyclosporine and minoxidil therapy. A review of drug-induced hypertrichosis is presented.
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References
1.
EblingFJ. Biology of hair follicles. In: FitzpatrickTBEisenAZWolffKFreedbergIMAustenKF, eds. Dermatology in general medicine. 3rd ed.New York: McGraw-Hill, 1987: 213–9.
2.
BertolinoAPFreedbergIM. Disorders of epidermal appendages and related disorders. In: FitzpatrickTBEisenAZWolffKFreedbergIMAustenKF, eds. Dermatology in general medicine. 3rd ed.New York: McGraw-Hill, 1987: 627–51.
3.
RettmasterRSLoriauxDL. Hirsutism. Ann Intern Med1987; 106: 95–107.
4.
LinasSLNiesAS. Minoxidil. Ann Intern Med1981; 94: 61–5.
5.
SinaikoARO'DeaRFMirkinBL. Clinical response of hypertensive children to long-term minoxidil therapy. J Cardiovasc Pharmacol1980; 2 (suppl 2):S181–8.
6.
MakkerSPMoorthyB. Rebound hypertension following minoxidil withdrawal. J Pediatr1980; 96: 762–6.
7.
EarhartRNBallJNussDDAelingJL. Minoxidil-induced hypertrichosis: Treatment with calcium thioglycolate depilatory. South Med J1977; 70: 442–3.
8.
BurtonJLMarshallA. Hypertrichosis due to minoxidil. Br J Dermatol1979; 101: 593–5.
9.
BunkerCBDowdPM. Alterations in scalp blood flow after the epicutaneous application of 3% minoxidil and 0.1% hexyl nicotinate in alopecia (letter). Br J Dermatol1987; 117: 668–9.
LindholmAPousetteACarlstromKKlintmalmG. Ciclosporin-associated hypertrichosis is not related to sex hormone levels following renal transplantation. Nephron1988; 50: 199–204.
13.
YocumDEKlippelJHWilderRL. Cyclosporin A in severe treatment refractory rheumatoid arthritis. Ann Intern Med1988; 100: 863–9.
14.
SchmidtJBGebhartWKopsaHSponaJ. Does cyclosporin A influence sex hormone level?Exp Clin Endocrinol1986; 88: 207–11.
15.
PrenenMLedoux-CorbusierM. Hormonal contraceptives and dermatology. Contraception1971; 4: 79–89.
16.
BatzerFR. Measurements of androgenicity—the spectrum of progestogen activity. J Reprod Med1986; 31 (suppl 9):848–64.
17.
LassusAHalmeKEskelinenARankiAPuskaPSaloO. Treatment of vitiligo with oral methoxsalen and UVA. Photodermatology1984; 1: 170–3.
18.
SinghGLalS. Hypertrichosis and hyperpigmentation with systemic psoralen treatment (letter). Br J Dermatol1967; 79: 501–3.
19.
RampenFHJ. Hypertrichosis in PUVA-treated patients. Br J Dermatol1983; 109: 657–60.
AtayaKAbbasiAMercadoAMoghissiKSKartaginerJ. Bone density and reproductive hormones in patients with neuroleptic-induced hyperprolactinemia. Fertil Steril1988; 50: 876–81.
22.
WielandRG. Hirsutism, obesity, and phenothiazine therapy (letter). JAMA1979; 242: 414.
23.
BraithwaiteSSEmanueleMACollinsS. Neuropsychiatric hirsutism (letter). Ann Intern Med1989; 110: 748–9.
24.
BurtonJLSchuttWHCaldwellIW. Hypertrichosis due to diazoxide. Br J Dermatol1975; 93: 707–11.
25.
KoblenzerPJBakerL. Hypertrichosis lanuginosa associated with diazoxide therapy in prepubertal children: A clinicopathologic study. Ann NY Acad Sci1968; 150: 373–82.
26.
ParkerLNLifrakETOdellWD. Lack of a gonadal or adrenal androgenic mechanism for the hypertrichosis produced by diazoxide, phenytoin and minoxidil. Biochem Pharmacol1982; 31: 1948–50.
27.
HallengrenBHokfeltB. Increase of serum androgens during diazoxide treatment (letter). Lancet1984; 2: 1044–5.
28.
LevantineAAlmeydaJ. Cutaneous reactions to anticonvulsants. Br J Dermatol1972; 87: 646–9.
29.
HerranzJLArmijoJAArteagaR. Clinical side effects of phenobarbital, primidone, phenytoin, carbamazepine, and valproate during monotherapy in children. Epilepsia1988; 29: 794–804.
30.
WeissIS. Hirsutism after chronic administration of acetazolamide. Am J Ophthalmol1974; 78: 327–8.
31.
GalanopoulouVSkopoukiFNMoutsopoulosHM. Nandrolone decanoate (deca-durabolin) in primary Sjogren's syndrome: A double blind pilot study. Clin Exp Rheumatol1988; 6: 53–7.
32.
ShefferALFearonDTAustenKF. Hereditary angioedema: A decade of management with stanozolol. J Allergy Clin Immunol1987; 80: 855–60.
33.
BarbieriRLEvansSKistnerRW. Danazol in the treatment of endometriosis: Analysis of 100 cases with a four year follow-up. Fertil Steril1982; 37: 737–46.
34.
FentonDAEnglishJSWilkinsonJD. Reversal of male-pattern baldness, hypertrichosis, and accelerated hair and nail growth in patients receiving benoxaprofen. Br Med J1982; 284: 1228–9.
35.
FentonDAWilkinsonJD. Milia, increased nail growth and hypertrichosis following treatment with benoxaprofen. J R Soc Med1983; 76: 525–7.
36.
HollmanGAAllenDB. Overt glucocorticoid excess due to inhaled corticosteroid therapy. Pediatrics1988; 81: 452–5.
37.
FelixRHSmithAGStevensonCJ. Skin disorders. In: DaviesDM, ed. Textbook of adverse drug reactions. 3rd ed.New York: Oxford University Press, 1985: 473–93.
38.
RookADawberR. Diseases of the hair and scalp. Boston: Blackwell Scientific Publications, 1982: 233–59.
39.
KologluSBaskalNKologluLBLaleliYTüccarE. Hirsutism due to the treatment with L-thyroxine in patients with thyroid pathology. Endocrinologie1988; 26: 179–85.
40.
PembrokeACMartenRH. Unusual cutaneous reactions following diphtheria and tetanus immunization. Clin Exp Dermatol1979; 4: 345–8.
41.
GoldfienAMonroeSE. The ovaries. In: GreenspanFSForshamPH, eds. Basic and clinical endocrinology. 2nd ed.Los Altos, CA: Lange Medical Publications, 1986: 385–430.