A retrospective review of neuroleptic dosages over a five-year period in 19 chronic schizophrenic patients revealed that the majority (85 percent) had either consistent yearly increases or decreases in dosage, although clinical status remained unchanged. The authors present differences in adverse effects between the two groups and discuss the implications of their findings for the concepts of neuroleptic drug tolerance and supersensitivity psychosis.
DAVISKL, HOLLISTERLE, FRITZWC. Induction of dopaminergic mesolimbic receptor supersensitivity by haloperidol.Life Sci1978; 23: 1543–8.
5.
CSERNANSKYJ, HOLLISTERLE. Probable case of supersensitivity psychosis.Hosp Formul1982; 3: 395–9.
6.
PALMSTIERNAT, WISTEDTB.Absence of acquired tolerance to neuroleptics in schizophrenic patients.Am J Psychiatry1987; 144: 1084–5.
7.
CASEYDE, GERLACHJ.Tardive dyskinesia: what is the long-term outcome? In: CaseyDE, GardosG, eds. Tardive dyskinesia and neuroleptics: from dogma to reason.Washington, DC: APA Press, 1986: 76–97.
8.
CHOUINARDG, STEINBERGS.New clinical concepts on neurolepticinduced supersensitivity disorders: tardive dyskinesia and supersensitivity psychosis. In: StancerHC, GarfinkelPE, RakoffVM eds. Guidelines for the use of psychoactive drugs.New York: Spectrum Publications, 1984: 241–9.
9.
CHOUINARDG, ANNABELL, ROSS-CHOUINARDA.Supersensitivity psychosis and tardive dyskinesia: a survey in schizophrenic outpatients.Psychopharmacol Bull1986; 22: 891–6.
10.
WEINBERGERDR, BIGELOWLB, KLEINST, WYATTRJ. Drug withdrawal in chronic schizophrenia patients in search of neuroleptic-induced supersensitivity psychosis.J Clin Psychopharmacol1981; 1: 120–3.
11.
ANDREWSP, HALLJN, SMITHRP. A controlled trial of phenothiazine withdrawal in chronic schizophrenia patients.Br J Psychiatry1976; 128: 451–8.
12.
HOGARTYGE, ULRICHRF, MUSSAREF, ARISTIGUETAN.Drug discontinuation among long-term, successfully maintained schizophrenic outpatients.Dis Nerv Sys1976; 37: 494–501.
13.
HUNTJI, SINGHH, SIMPSONGM. Neuroleptic induced supersensitivity psychosis: retrospective study of schizophrenic inpatients.J Clin Psychiatry1988; 49: 258–61.