A 23-year-old woman with asthma developed severe heartburn while using beclomethasone dipropionate. Esophageal candidiasis was diagnosed on endoscopy and confirmed by biopsy. Subsequent studies revealed mild hypogammaglobulinemia and mild impairment of neutrophil candidacidal activity, the significance of which is unknown. Esophageal candidiasis associated with the use of inhaled beclomethasone has not been previously reported.
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References
1.
WilliamsMHJr. Conference on the scientific basis of respiratory therapy: Aerosol therapy: Steroid and antibiotic aerosols. Am Rev Respir Dis1974; 110 (6 pt 2): 122–8.
2.
ToogoodJHLefcoeNMHainesDSM. Minimum dose requirement of steroid-dependent asthmatic patients for aerosol beclomethasone and oral prednisone. J Allergy Clin Immunol1978; 61: 355–64.
3.
Morrow-BrownHStoreyGJacksonFA. Beclomethasone dipropionate aerosol in long-term treatment of perennial and seasonal asthma in children and adults: A report of five and a half years' experience in 600 asthmatic patients. Br J Clin Pharmacol1977; 4: 259S–67S.
4.
CaytonRMNunnAJTurner-WarwickMClarkTJHFoxW. Double-blind trial comparing two dosage schedules of beclomethasone dipropionate aerosol with a placebo in chronic bronchial asthma. Br J Dis Chest1979; 73: 121–32.
5.
SmithMJHodsonME. High-dose beclomethasone inhaler in the treatment of asthma. Lancet1983; 1: 265–9.
6.
ToogoodJHLefcoeNMHainesDSM. A graded dose assessment of the efficacy of beclomethasone dipropionate aerosol for severe chronic asthma. J Allergy Clin Immunol1977; 59: 298–308.
7.
ToogoodJHJenningsBGreenwayRWChuangL. Candidiasis and dysphonia complicating beclomethasone treatment of asthma. J Allergy Clin Immunol1980; 65: 145–53.
8.
McAllenMKKochanowskiSJShawKM. Steroid aerosols in asthma: An assessment of betamethasone valerate and a 12 month study of patients on maintenance treatment. Br Med J1974; 1: 171–5.
9.
ToogoodJHBaskervilleJJenningsBLefcoeNMJohanssonSA. Use of spacers to facilitate inhaled corticosteroid treatment of asthma. Am Rev Respir Dis1984; 129: 723–9.
10.
NobleMAWhittakerJSMangalAKCarterCJFreemanHJ. Candida esophagitis in a male homosexual with defective neutrophil function. A “pseudo-AIDS” syndrome. Can J Gastroenterol1987; 1: 33–5.
11.
DolleryCTDaviesDSConnollyME. Differences in the metabolism of drugs depending upon their routes of administration. Ann NY Acad Sci1971; 179: 108–12.
