Fixed eruption of the penis, due to co-trimoxazole, is described in two boys.
The eruption was accompanied by severe swelling of the penis, urine retention, and pain during micturition. The migration inhibiting factor assay for co-trimoxazole was negative, but the mast cell degranulation test was strongly positive, suggesting reaginic hypersensitivity reaction.
WallaceHJHymanAB. Disorder of external genitalia. Drug eruptions. In: FitzpatricTBEisenAZWolffKFreedbergIAustenKF, eds. Dermatology in general medicine. New York: McGraw Hill, 1979: 911.
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AderkaDLivniESharonSPinkhasJ. The migration inhibition factor test for identification of hypersensitivity reactions to drugs. Ann Allergy1986; 56: 341–4.
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SchwartzJKlopstockADuvdevaniP ZibertHonigS. Detection of hypersensitivity by indirect rat mast cell degranulation. Int Arch Allergy1965; 26: 333–9.
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TalbotMD. Fixed genital drug eruption. Practitioner1980; 224: 823–4.
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TurkJL. Immunological mechanisms in the reaction between drugs and the skin. J Clin Pathol [Suppl] (Roy Coll Pathol)1975; 9: 58–61.
