During the approximately five years (1981–86) that piroxicam has been available in South Africa, the Medicines Safety Centre has received 31 reports of adverse reactions associated with this drug. Among these are two reactions not previously recorded in the literature, paresthesia and hair loss. This article records drug events associated with piroxicam worldwide and tabulates those received by the Centre.
WeintraubMJacoxRFAngevineCDAtwaterEC.Piroxicam in rheumatoid arthritis: a controlled clinical trial with novel assessment techniques.J Rheumatol1977; 4: 393–404.
2.
PittsNE.Ubersicht uber die mit Piroxicam in klinischen Untersuchungen gewonnenen Erfahrungen.Aktuel Rheumatol1980; 5: 53–55.
VrhovacB.Anti-inflammatory analgesics and drugs used in gout. In: DukesMNG, ed. Meyler's side effects of drugs.10th ed.Amsterdam: Elsevier, 1984: 170–1.
5.
FokKHGeorgePJMVicaryFR.Peptic ulcers induced by pirox-icam.Br Med J1985; 290: 117.
6.
EmeryPGrahameR.Gastrointestinal blood loss and piroxicam (letter).Lancet1982; 1: 1302–3.
7.
LaakeKKjeldaasLBorchgrevinkCF.Side-effects of pirox-icam (Feldene).Acta Med Scand1984; 215: 81–3.
8.
WardKWeirDG.Piroxicam and upper gastrointestinal haemor-rhage.Ir Med J1982; 75: 10–11.
9.
PiskoEJRahmanMATurnerTAAgudecoCA.Long-term efficacy and safety of piroxicam in the treatment of rheumatoid arthritis.Curr Ther Res1980; 27: 852–9.
10.
AndoGJellhedenBSodergrenJ.Toleration of piroxicam.Int Med1983; 3: 37–41.
11.
MurphyJR.Piroxicam in the treatment of acute gout: a multicen-tre open study in general practice.J Int Med Res1979; 7: 507.
12.
TauschGEberlRBrollH.Piroxicam and rheumatoid arthri-tis: long-term open treatment. In: Pyroxicam.Proceedings of the Royal Society of Medicine International Congress Symposium Series, 1978;1: 59–64.
13.
MakisaraPNuotioP.Piroxicam and rheumatoid arthritis: comparative study of piroxicam and ibuprofen. In: Pyroxicam.]Proceedings of the Royal Society of Medicine International Congress Symposium Series, 1978; 1: 65–70.
14.
ZizicTMSuttonJDStevensMB.Piroxicam and osteoarthritis: a controlled study. In: Pyroxicam.Proceedings of the Royal Society of Medicine International Congress Symposium Series1978; 1: 71–6.
15.
NussdorfRT.Piroxicam and acute musculoskeletal disease: a double-blind 14-day study comparing piroxicam and phenyl-butazone. In: Pyroxicam.Proceedings of the Royal Society of Medicine International Congress Symposium Series, 1978; 1: 93–6.
16.
PittsNEProctorRR.Summary: efficacy and safety of pirox-icam. In: Pyroxicam.Proceedings of the Royal Society of Medicine International Congress Symposium Series, 1978; 1: 97–101.
17.
DessainIEstabrooksTFGordonAJ.Piroxicam in the treat-ment of osteoarthrosis: a multicentre study in general practice involving 1218 patients.J Int Med Res1979; 7: 335–43.
18.
BaloghZPapzoglouSNMacleodMBuchananWW.A crossover clinical trial of piroxicam, indomethacin and ibuprofen in rheumatoid arthritis.Curr Med Res Opin1979; 6: 148–53.
19.
TelghagH.Safety and efficacy of piroxicam in the treatment of osteoarthrosis.Eur J Rheumatol Inflamm1978; 1: 352–5.
20.
RadiIMatosoLPosmantirAPaplexiouP.Safety and efficacy of piroxicam in the treatment of ankylosing spondylitis.Eur J Rheumatol Inflamm1978; 1: 349–51.
21.
VernickDMKellyJH.Sudden hearing loss associated with piroxicam.Am J Otol1986; 7: 97–8.
22.
GoebelKMMueller-BrodmanW.Reversible overt nephropathy with Henoch-Schonlein purpura due to piroxicam.Br Med J1982; 284: 311–2.
23.
Pyroxicam (editorial). Drugs of Today1980; 16:115.
24.
HoganDJBlockaKLN.Erythema annulare centrifugum associated with piroxicam.J Am Acad Dermatol1985; 13: 840–1.
BertailMACavelierBCivatteJ.Reaction au piroxicam (Feldene) a type d'ectodermose erosive pluri-orificielle.Ann Dermatol Venereol1982; 109: 261–2.
27.
RoujeauJCRevuzITouraineR.Syndrome de Lyell au cours d'un raitement par un novel antiinflammatoire.Nouv Presse Med1981; 10: 3407–8.
28.
Pitte-BrionBDe BastCChameumE, Pemphigus superficiel apperu lor du traitement d'une polyarthrite rhumatoide par D-penicillamine et piroxicam (Feldene).Dermatologica1985; 170: 297–301.
29.
MartinRLMcsweeneyGWSchneiderJ.Fatal pemphigus vulgaris in a patient taking piroxicam (letter).N Engl J Med1983; 309: 795–6.
30.
JeanmouginMRibriouxAJanierMPemphigus seborrhéique au sous d'une polyarthrite rheumatoïde traitée par D-pénicillamine puis par piroxicam (letter).Ann Dermatol Venereol1983; 110: 476.
31.
SternRS.Phototoxic reactions to piroxicam and other nonsteroidal antiinflammatory agents (letter).N Engl J Med1983; 309: 186–7.
32.
FaureMGoujonCPerrotHHermierCDorveauxODeteixP.Accidents cutanes provoques par le piroxicam.Ann Dermatol Venereol1982; 109: 255–8.
33.
FjellnerB.Photosensitivity induced by piroxicam.Acta Derm Venereol1983; 63: 557–8.
34.
SachsR.Phototoxic reactions to piroxicam and other nonste-roidal antiinflammatory agents (letter).N Engl J Med1983; 309: 186–7.
35.
BraunsteinBL.Dyshidrotic eczema associated with piroxicam photosensitivity.Cutis1985; 35: 485–6.
36.
WeigandDA.Piroxicam induced photosensitivity (letter).J Am Acad Dermatol1985; 12: 373–4.
37.
LeeSHFawcettVPreeceJM.Aplastic anemia associated with piroxicam (letter).Lancet1982; 1: 1186.
38.
SpectorSLMorrisHGSelnerJC.Clinical responses of serum prostaglandin levels in aspirin idiosyncrasy.Chest1981; 80: 676–81.
39.
BoxJBoxPTurnerRPiskoE.Piroxicam and rheumatoid arthritis: a double blind 16-week study comparing piroxicam and phenylbutazone. In: Pyroxicam.Proceedings of the Royal Society of Medicine International Congress Symposium Series, 1978; 1: 40–5.
LeeKH.Piroxicam induced adverse reactions (letter).Korean Central J Med1979; 36: 425.
42.
FowlerRWArnoldKG.Non-steroidal analgesic and antiinflammatory agents (letter).Br Med J1983; 287: 835.
43.
MillerKPLazerEJFotinoS.Severe hyperkalemia during piroxicam therapy.Arch Intern Med1984; 144: 2414–5.
44.
GrossmanLAMossS.Piroxicam and hyperkalemic acidosis (letter).Ann Intern Med1983; 99: 282.
45.
SpectorSLMorrisHGSelnerJC.Pulmonary, prostaglandin and clinical response of asthmatic patients with aspirin idiosyncrasy to a new nonsteroid anti-inflammatory substance compared to aspirin.J Allergy Clin Immunol1979; 65: 154–5.
46.
GuntherREggDHeroldM.Efficacy and safety of piroxicam and indomethacin in the treatment of musculoskeletal disor-ders: a double blind comparative study.Z Rheumatol1979; 38: 330–3.
47.
WidmarkP.Safety and efficacy of piroxicam in the treatment of acute gout.Eur J Rheumatol Inflamm1978; 1: 346–8.
48.
SteigerwaldJC.Piroxicam and rheumatoid arthritis: a doubleblind 16-week study comparing piroxicam and indomethacin.Eur J Rheumatol Inflamm1978; 1: 360–4.
FraisMABurgessEDMitchellLB.Piroxicam-induced renal failure and hyperkalemia (letter).Ann Intern Med1983; 99: 129–30.
54.
SchattenkirchnerMMuller-FassbenderHMelzerHHenzeK.Effectiveness of piroxicam in the treatment of patients with ankylosing spondylitis.Am J Med1982; 72(suppl 2A):54–7.
55.
LeeSMO'BRIENCJWilliamsRWhitakerSGouldSR.Subacute hepatic necrosis induced by piroxicam.Br Med J1986; 293: 540–1.
56.
ZimmermanHJ.Anti-inflammatory and other drugs employed in the treatment of rheumatic and musculoskeletal disease. In: Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver.New York: Appleton Century Crofts,1980: 418–35.
57.
CommandreF.Double blind comparative study of piroxicam and indomethacin in acute locomotor affections linked with sports activity (abstract).Eur J Rheumatol Inflamm1983; 6: 113.
58.
Mueller-FassbenderHSchattenkirchnerM.Piroxicam and ankylosing spondylitis: an open long-term study. In: Pyrox-icam.Proceedings of the Royal Society of Medicine Interna-tional Congress Symposium Series, 1978; 1: 83–8.
