Cimetidine and Gastric Cancer

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Elder JB , Gillespie IE , Ganfuli PC . Cimetidine and gastric cancer. Lancet 1979; 2: 1005–6.

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Hawker PC , Muscroft TJ , Keighley MR . Gastric cancer after cimetidine in patient with two negative pretreatment biopsies. Lancet 1980; 2: 709–10.

Stockbruegger RW . Bacterial overgrowth as a consequence of reduced gastric acidity. Scand J Gastroenterol 1985; 111(suppl): 7–16.

Ruddell WS . Gastric cancer in patients who have taken cimetidine (letter). Lancet 1979; 1: 1234.

Lijinsky W , Reuber M . Comparison of nitrosocimetidine with nitrosomethylnitroguanidine in chronic feeding tests in rats. Cancer Res 1984; 44: 447–9.

Thomas JM , Misiewicz G . Histamine H₂ receptor antagonists in the short- and long-term treatment of duodenal ulcer. Clin Gastroenterol 1984; 13: 501–41.

Reed PI , Haines K , Smith PL , House PLJ , Walter CL . Effect of cimetidine on gastric juice N-nitrosamine concentration. Lancet 1981; 1: 553–6.

Ruddell WSJ , Axon ATR , Findlay JM , Bartholomew BA , Hill MJ . Effect of cimetidine on the gastric bacterial flora. Lancet 1980; 1: 672–4.

Stockbruegger RW , Cotton PB , Eugenides N , Bartholomew BA , Hill MJ , Walters CL . Intragastric nitrites, nitrosamines, and bacterial overgrowth during cimetidine treatment. Gut 1982; 23: 1048–54.

Muscroft TJ , Bourdon DW , Youngs DJ , Keighley MR . Cimetidine is unlikely to increase formation of intragastric N-nitroso-compounds in patients taking a normal diet. Lancet 1981; 1: 408–10.

Milton-Thompson GJ , Ahmet Z , Lightfoot NF . Intragastric acidity, bacteria, nitrite, and N-nitroso compounds before, during and after cimetidine treatment. Lancet 1982; 2: 1091–5.

Barnard J , Darkin DW , Howard OM , Lightfoot NF , Miltonthompson GJ , Viney NJ . N-nitroso compounds in cimetidine-treated duodenal ulcer patients (abstract). Gut 1983; 24: A974.

Peterson WL , Richardson CT . Sustained fasting achlorhydria: a comparison of medical regimens. Gastroenterology 1985; 88: 666–9.

Jensen DE . Deoxyribonucleic acid methylation in human cells exposed to nitrosocimetidine. Biochem Pharmacol 1981; 30: 2864–7.

Ichinotsubo D , Mackinnon EA , Liu C , Rice S , Mower H . Mutagenicity of nitrosated cimetidines. Carcinogenesis 1981; 2(4): 261–4.

Foster AB , Jarman M , Manson D . Structure and reactivity of nitrosocimetidine. Cancer Lett 1980; 9: 47–52.

Crean GP , Leslie GB , Roe FJ . Cimetidine and gastric cancer: negative studies in dogs. Lancet 1979; 2: 797–8.

Jensen D . Denitrosation as a determinant of nitrosocimetidine in vivo activity. Cancer Res 1983; 43: 5258–67.

Brimblecombe RW , Leslie GB , Walker TF . Toxicology of cimetidine. Hum Toxicol 1985; 4: 13–25.

Anderson LM , Giner-Sorolla A , Haller IM , Budinger JM . Effects of cimetidine, nitrite, cimetidine plus nitrite, and nitrosocimetidine on tumors in mice following transplacental plus chronic lifetime exposure. Cancer Res 1985; 45: 3561–6.

Crean GP , Morson BC , Leslie GB , Roe FJ . Cimetidine: further evidence of noncarcinogenicity in dogs (letter). N Engl J Med 1981; 304: 672.

Habs M , Eisenbrand G , Schmahl D . No evidence of carcinogenicity of N-nitrosocimetidine in rats. Hepatogastroenterology 1982; 29: 265–6.

Nee J , O'HIGGINS N , Osborne DH , Purdy S . The role of histamine antagonists on the development of experimental cancer in the rat. Ir J Med Sci 1984; 153(10): 332–5.

Collin-Jones DG , Langman MJ , Lawson DH , Vessey MP . Post-marketing surveillance of the safety of cimetidine: 12 month mortality report. Br Med J 1983; 286: 1713–6.

Collin-Jones DG , Langman MJ , Lawson DH , Vessey MP . Cimetidine and gastric cancer: preliminary report from postmarketing surveillance study. Br Med J 1982; 285: 1311–3.

Porter JB , Janeway CM , Hunter JR . Absence of causal association between cimetidine and gastric cancer. Gastroenterology 1984: 4: 987–8.

Porter JB , Jick H , Perera DR , Ylvisaker JT , Hunter JR . Long-term follow-up study of cimetidine. Pharmacotherapy 1984; 4: 381–4.

Waterhouse J , Muir C , Shanmugaratnam K , Powell J , eds. Cancer in five continents. Vol. 4. Lyon: WHO International Agency for Research on Cancer, 1982; IARC Scientific Publication no. 42.

Hill MJ . Gastric cancer in patients who have taken cimetidine (letter). Lancer 1979; 1: 1235.

Stoddard CJ , Smith JA , Johnson AG . Cimetidine, delay in diagnosis, and carcinoma of the stomach. Lancet 1980; 2: 199–200.