Abstract
Abstract
Spanish
French
This study was conducted in a nonteaching community hospital to characterize the use of prophylactic antibiotics in patients undergoing total joint replacements by orthopedic surgeons in private practice. Of the 101 patients studied, 43 were started on antibiotics too early, 32 were left on the drugs for too long a period, and 33 received subsequent oral antibiotics without identifiable reason. Seventy-nine (78.2 percent) received 8 g/d of a first- or second-generation cephalosporin for prophylaxis. None of the patients received cefazolin 1 g q8h.
Get full access to this article
View all access options for this article.
References
1.
Dipiro
JT
Record
KE
Schanzenbach
KS
Bivins
BA
. Antimicrobial prophylaxis in surgery: Parts 1 and 2 . Am J Hosp Pharm
1981 ; 38 : 320 –4 , 487 –94 .
2.
Hirschmann
JV
Inui
TS
. Antimicrobial prophylaxis: A critique of recent trials . Rev Infect Dis
1980 ; 2 : 1 –23 .
3.
Guglielmo
BJ
Hohn
DC
Koo
PJ
Hunt
TK
Sweet
RL
Conte
JE
. Antibiotic prophylaxis in surgical procedures: A critical analysis of the literature . Arch Surg
1983 ; 118 : 943 –55 .
4.
Van Scoy
RE
Wilkowske
CJ
. Prophylactic use of antimicrobial agents . Mayo Clin Proc
1983 ; 58 : 241 –5 .
5.
Sandusky
WR
. Use of prophylactic antibiotics in surgical patients . Surg Clin North Am
1980 ; 60 : 83 –92 .
6.
Ronald
AR
. Pros and cons of antimicrobial prophylaxis in surgery . Can J Surg
1981 ; 24 : 113 –6 .
7.Antimicrobial prophylaxis for surgery . Med Lett Drugs Ther
1983 ; 25 : 113 –6 .
8.
Gleckman
R.
Gantz
NM
. Cost-effective antibiotic prescribing . Pharmacotherapy
1983 ; 5 : 239 –48 .
9.
Burnakis
TG
. Surgical antimicrobial prophylaxis: Principles and guidelines . Pharmacotherapy
1984 ; 4 : 248 –71 .
10.
Ericson
C.
Lidgren
L.
Lindberg
L.
Cloxacillin in the prophylaxis of postoperative infections of the hip . J Bone Joint Surg Am
1973 ; 55 : 808 –13 .
11.
Hill
C.
Flamant
R.
Maxas
F.
Evrard
J.
Prophylactic cefazolin versus placebo in total hip replacement . Lancet
1981 ; 1 : 795 –7 .
12.
Boyd
RJ
Burke
JF
Colton
T.
A double-blind clinical trial of prophylactic antibiotics in hip fractures . J Bone Joint Surg Am
1973 ; 55 : 1251 –8 .
13.
Burnett
JW
Gustilo
RB
Williams
DN
Kind
AC
. Prophylactic antibiotics in hip fractures: A double-blind, prospective study . J Bone Joint Surg Am
1980 ; 62 : 457 –62 .
14.
Burke
JF
. The effective period of preventive antibiotic action in experimental incisions and dermal lesions . Surgery
1961 ; 50 : 161 –8 .
15.
Alexander
JW
Altemeier
WA
. Penicillin prophylaxis of experimental staphylococcal wound infections . Surg Gynecol Obstet
1965 ; 120 : 243 –54 .
16.
Shapiro
M.
Townsend
TR
Rosner
B.
Kass
EH
. Use of antimicrobial drugs in general hospitals: Patterns of prophylaxis . N Engl J Med
1979 ; 301 : 351 –5 .
17.
Crossley
K.
Gardner
LC
. Antimicrobial prophylaxis in surgical patients . JAMA
1981 ; 245 : 722 –6 .
18.
Pollard
JP
Hughes
Spf
Scott
JE
Evans
MJ
Benson
MKD
. Antibiotic prophylaxis in total hip replacement . Br Med J
1979 ; 1 : 707 –9 .
19.
Quintiliani
R.
Nightingale
CH
. Cefazolin . Ann Intern Med
1978 ; 89 : 650 –6 .
20.
Jogerst
GJ
Dippe
SE
. Antibiotic use among medical specialties in a community hospital . JAMA
1981 ; 245 : 842 –6 .
21.
Vladeck
BC
. Medicare hospital payment by diagnosis-related groups . Ann Intern Med
1984 ; 100 : 576 –91 .
22.
Dudley
M.
Barriere
S.
Cost comparisons among antimicrobial agents (letter) . N Engl J Med
1982 ; 307 : 689 .
23.
Dudley
MN
Quintiliani
R.
Nightingale
CH
. Review of cefonicid, a long-acting cephalosporin . Clin Pharm
1984 ; 3 : 23 –32 .
24.
Pontzer
RE
Kaye
D.
Cefonicid: A long-acting, second generation cephalosporin. Antimicrobial activity, pharmacokinetics, clinical efficacy and adverse effects . Pharmacotherapy
1984 ; 4 : 325 –33 .
25.Cefonicid sodium (Monocid) . Med Lett Drugs Ther
1984 ; 26 : 71 –2 .
26.Ceforanide (Precef) . Med Lett Drugs Ther
1984 ; 26 : 91 –2 .
27.
Rapp
RP
Blue
D.
The role of the extended half-life second-generation cephalosporins in surgical prophylaxis . Drug Intell Clin Pharm
1985 ; 19 : 214 –6 .